Highly diastereo- and enantioselective direct aldol reactions of cycloketones with aldehydes catalyzed by a trans-4-tert-butyldimethylsiloxy-L-proline amide

被引：41

作者：

He, Long ^{[1
]}

Jiang, Jun

Tang, Zhuo

Cui, Xin

Mi, Ai-Qiao

Jiang, Yao-Zhong

Gong, Liu-Zhu

机构：

[1] China W Normal Univ, Coll Chem & Chem Engn, Nanchong 637002, Peoples R China

[2] Chinese Acad Sci, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Union Lab Asymmetr Synth, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 02期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tetasy.2007.01.028

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An organocatalyst derived from trans-4-hydroxy-L-proline and (1S,2S)-1,2-diphenyl-2-aminoethanol catalyzes the direct aldol reactions of cycloketones with. a wide scope of aldehydes in high yields and with excellent diastereoselectivities of up to > 99:1 and enantioselectivities of up to > 99% ee. (c) 2007 Published by Elsevier Ltd.

引用

页码：265 / 270

页数：6

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