Liposome based systems for systemic siRNA delivery: Stability in blood sets the requirements for optimal carrier design

被引：166

作者：

Buyens, Kevin ^{[1
]}

De Smedt, Stefaan C. ^{[1
]}

Braeckmans, Kevin ^{[1
,8
]}

Demeester, Joseph ^{[1
]}

Peeters, Liesbeth ^{[2
]}

van Grunsven, Leo A. ^{[2
]}

du Jeu, Xavier de Mollerat ^{[3
]}

Sawant, Rupa ^{[4
,5
]}

Torchilin, Vladimir ^{[4
,5
]}

Farkasova, Katarina ^{[6
]}

Ogris, Manfred ^{[6
]}

Sanders, Niek N. ^{[7
]}

机构：

[1] Univ Ghent, Lab Gen Biochem & Phys Pharm, Fac Pharm, B-9000 Ghent, Belgium

[2] Free Univ Brussels, Dept Cell Biol, Liver Cell Biol Lab, B-1090 Brussels, Belgium

[3] Invitrogen Corp, Carlsbad, CA 92008 USA

[4] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA 02115 USA

[5] Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA 02115 USA

[6] Univ Munich, Dept Pharm, Ctr Drug Res, D-81377 Munich, Germany

[7] Univ Ghent, Fac Vet Med, Dept Nutr Genet & Ethol, Lab Gene Therapy, B-9820 Merelbeke, Belgium

[8] Univ Ghent, Ctr Nano & Biophoton, B-9000 Ghent, Belgium

来源：

JOURNAL OF CONTROLLED RELEASE | 2012年 / 158卷 / 03期

关键词：

Liposome; RNAi; Delivery; Encapsulation; Stability; RNA INTERFERENCE; IN-VIVO; PARTICLE-SIZE; ANTISENSE OLIGONUCLEOTIDES; PEGYLATED LIPOSOMES; CLEARANCE; LIVER; PEG; NANOPARTICLES; EFFICIENT;

D O I：

10.1016/j.jconrel.2011.10.009

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

siRNA therapeutics are currently regarded as promising candidates to make a leap forward in the search for treatments of various hard to cure diseases. In order to exploit the full potential of siRNA based therapeutics, development of delivery systems that can efficiently guide the siRNA molecules to their target without major side effects will be the key to success. Lipid based delivery systems, originating from earlier research in the fields of gene delivery, are the most studied candidates for siRNA delivery. Here we discuss the requirements that need to be met by these siRNA delivery systems to ensure adequate stability after systemic application and subsequent deposition in the target tissue. The encountered hurdles in the blood stream and the solutions proposed in literature are discussed. (C) 2011 Elsevier B. V. All rights reserved.

引用

页码：362 / 370

页数：9

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