Interleukin-10 and gp130 cytokines in human multiple myeloma

被引：32

作者：

Klein, B ^{[1
]}

Lu, ZY ^{[1
]}

Gu, ZJ ^{[1
]}

Costes, V ^{[1
]}

Jourdan, M ^{[1
]}

Rossi, JF ^{[1
]}

机构：

[1] INSERM U475, F-34197 Montpellier, France

来源：

LEUKEMIA & LYMPHOMA | 1999年 / 34卷 / 1-2期

关键词：

multiple myeloma; interleukin-10; GP; 130; cytokines;

D O I：

10.3109/10428199909083381

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin (IL)-10 is a critical cytokine involved in the terminal differentiation of B cells into plasma cells. IL-10 is also involved in multiple myeloma, a malignant plasma cell disorder. IL-6 and, more generally the cytokines activating the gp130 IL-6 transducer, are major survival and proliferation factors of myeloma cells. IL-10 is also a growth factor of malignant plasma cells, produced by myeloma cells from about half the patients and is detected in the plasma of patients with plasma cell leukemia or solitary plasmacytoma. The myeloma cell growth activity of IL-10 is mediated through a gp130 cytokine, oncostatin M (OSM), that is frequently produced by myeloma cells. Myeloma cells fail to express OSM receptors but IL-IO, by inducing it, confers on them the sensivity to OSM.

引用

收藏

页码：63 / 70

页数：8

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