The Systematic Production of Cells for Cell Therapies

被引：201

作者：

Kirouac, Daniel C. ^{[1
]}

Zandstra, Peter W. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3E1, Canada

[2] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

[3] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E1, Canada

[4] Univ Hlth Network, McEwen Ctr Regenerat Med, Heart & Stroke Richard Lewar Ctr Excellence, Toronto, ON M5G 1L7, Canada

来源：

CELL STEM CELL | 2008年 / 3卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.stem.2008.09.001

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Stem cells have emerged as the starting material of choice for bioprocesses to produce cells and tissues to treat degenerative, genetic, and immunological disease. Translating the biological properties and potential of stem cells into therapies will require overcoming significant cell-manufacturing and regulatory challenges. Bioprocess engineering fundamentals, including bioreactor design and process control, need to be combined with cellular systems biology principles to guide the development of next-generation technologies capable of producing cell-based products in a safe, robust, and cost-effective manner. The step-wise implementation of these bioengineering strategies will enhance cell therapy product quality and safety, expediting clinical development.

引用

页码：369 / 381

页数：13

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