Plasma lipoproteins: genetic influences and clinical implications

被引:310
作者
Hegele, Robert A. [1 ,2 ]
机构
[1] Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada
[2] Univ Western Ontario, Schulich Sch Med & Dent, London, ON N6A 5K8, Canada
关键词
GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; FAMILIAL COMBINED HYPERLIPIDEMIA; LDL-CHOLESTEROL; SEVERE HYPERTRIGLYCERIDEMIA; CARDIOVASCULAR-DISEASE; ARTERY-DISEASE; LIPID-LEVELS; NONFASTING TRIGLYCERIDES; MYOCARDIAL-INFARCTION;
D O I
10.1038/nrg2481
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Susceptibility to the growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, including classical studies of monogenic dyslipidaemias, resequencing, phenomic analysis and, more recently, genome-wide association studies and analysis of metabolic networks. The genetic basis of plasma lipoprotein levels can now be modelled as a mosaic of contributions from multiple DNA sequence variants, both rare and common, with varying effect sizes. In addition to filling gaps in our understanding of plasma lipoprotein metabolism, the recent genetic advances will improve our ability to classify, diagnose and treat dyslipidaemias.
引用
收藏
页码:109 / 121
页数:13
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