共 29 条
Proteomics: A new diagnostic frontier
被引:70
作者:

Hortin, GL
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Dept Lab Med, Intramural Res Program, NIH Clin Ctr, Bethesda, MD 20892 USA

Jortani, SA
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Dept Lab Med, Intramural Res Program, NIH Clin Ctr, Bethesda, MD 20892 USA

Ritchie, JC
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Dept Lab Med, Intramural Res Program, NIH Clin Ctr, Bethesda, MD 20892 USA

Valdes, R
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Dept Lab Med, Intramural Res Program, NIH Clin Ctr, Bethesda, MD 20892 USA

Chan, DW
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Dept Lab Med, Intramural Res Program, NIH Clin Ctr, Bethesda, MD 20892 USA
机构:
[1] NIH, Dept Lab Med, Intramural Res Program, NIH Clin Ctr, Bethesda, MD 20892 USA
[2] Univ Louisville, Dept Pathol & Lab Med, Louisville, KY 40292 USA
[3] Emory Univ, Dept Pathol, Atlanta, GA 30322 USA
[4] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA
关键词:
D O I:
10.1373/clinchem.2006.067280
中图分类号:
R446 [实验室诊断];
R-33 [实验医学、医学实验];
学科分类号:
1001 ;
摘要:
Background: Analysis of proteins has been an integral part of the field of clinical chemistry for decades. Recent advances in technology and complete identification of the human genome sequence have opened. up new opportunities for analysis of proteins for clinical diagnostic purposes. Methods: Content of a recent conference of proteomics is summarized. Results: New analytical methods allow the simultaneous analysis of a large number of proteins in biological fluids such as serum and plasma, offering partial views of the complete set of proteins or proteome. Plasma presents many analytical challenges, such as the complexity of components, predominance of a few major components, and the large concentration range of components, but the number of proteins that can be detected in plasma has expanded dramatically from hundreds to thousands. At the same time, there is increased capability to detect structural variations of proteins. Recent studies also identified the, presence of complex sets of small protein fragments, in plasma. This set of protein fragments, the fragmentome or peptidome, is potentially a rich, source of information about physiologic and disease processes. Conclusions: Advances in proteomics offer great promise for the discovery of markers that might serve as the basis for new clinical laboratory tests. There are many challenges,, however, in the translation of newly discovered markers into clinical laboratory tests. (c) 2006 American Association for Clinical Chemistry.
引用
收藏
页码:1218 / 1222
页数:5
相关论文
共 29 条
[11]
Strategy for analysis of cardiac troponins in biological samples with a combination of affinity chromatography and mass spectrometry
[J].
Labugger, R
;
Simpson, JA
;
Quick, M
;
Brown, HA
;
Collier, CE
;
Neverova, I
;
Van Eyk, JE
.
CLINICAL CHEMISTRY,
2003, 49 (06)
:873-879

Labugger, R
论文数: 0 引用数: 0
h-index: 0
机构: Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada

Simpson, JA
论文数: 0 引用数: 0
h-index: 0
机构: Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada

Quick, M
论文数: 0 引用数: 0
h-index: 0
机构: Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada

Brown, HA
论文数: 0 引用数: 0
h-index: 0
机构: Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada

Collier, CE
论文数: 0 引用数: 0
h-index: 0
机构: Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada

Neverova, I
论文数: 0 引用数: 0
h-index: 0
机构: Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada

Van Eyk, JE
论文数: 0 引用数: 0
h-index: 0
机构: Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada
[12]
Comprehensive proteome analysis by chromatographic protein prefractionation
[J].
Lescuyer, P
;
Hochstrasser, DF
;
Sanchez, JC
.
ELECTROPHORESIS,
2004, 25 (7-8)
:1125-1135

Lescuyer, P
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Geneva, Biomed Prote Res Grp, Clin Chem Cent Lab, Geneva, Switzerland Univ Hosp Geneva, Biomed Prote Res Grp, Clin Chem Cent Lab, Geneva, Switzerland

Hochstrasser, DF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Geneva, Biomed Prote Res Grp, Clin Chem Cent Lab, Geneva, Switzerland Univ Hosp Geneva, Biomed Prote Res Grp, Clin Chem Cent Lab, Geneva, Switzerland

Sanchez, JC
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Geneva, Biomed Prote Res Grp, Clin Chem Cent Lab, Geneva, Switzerland Univ Hosp Geneva, Biomed Prote Res Grp, Clin Chem Cent Lab, Geneva, Switzerland
[13]
Independent validation of candidate breast cancer serum biomarkers identified by mass spectrometry
[J].
Li, JN
;
Orlandi, R
;
White, CN
;
Rosenzweig, J
;
Zhao, J
;
Seregni, E
;
Morelli, D
;
Yu, YH
;
Meng, XY
;
Zhang, Z
;
Davidson, NE
;
Fung, ET
;
Chan, DW
.
CLINICAL CHEMISTRY,
2005, 51 (12)
:2229-2235

Li, JN
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Orlandi, R
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

White, CN
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Rosenzweig, J
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Zhao, J
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Seregni, E
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Morelli, D
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Yu, YH
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Meng, XY
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Zhang, Z
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Davidson, NE
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Fung, ET
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

Chan, DW
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA
[14]
Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold
[J].
Liotta, LA
;
Petricoin, EF
.
JOURNAL OF CLINICAL INVESTIGATION,
2006, 116 (01)
:26-30

Liotta, LA
论文数: 0 引用数: 0
h-index: 0
机构:
George Mason Univ, Coll Arts & Sci, Ctr Appl Proteom & Mol Med, Manassas, VA 20110 USA George Mason Univ, Coll Arts & Sci, Ctr Appl Proteom & Mol Med, Manassas, VA 20110 USA

Petricoin, EF
论文数: 0 引用数: 0
h-index: 0
机构:
George Mason Univ, Coll Arts & Sci, Ctr Appl Proteom & Mol Med, Manassas, VA 20110 USA George Mason Univ, Coll Arts & Sci, Ctr Appl Proteom & Mol Med, Manassas, VA 20110 USA
[15]
High-resolution serum proteomic profiling of Alzheimer disease samples reveals disease-specific, carrier-protein-bound mass signatures
[J].
Lopez, MF
;
Mikulskis, A
;
Kuzdzal, S
;
Bennett, DA
;
Kelly, J
;
Golenko, E
;
DiCesare, J
;
Denoyer, E
;
Patton, WF
;
Ediger, R
;
Sapp, L
;
Ziegert, T
;
Lynch, C
;
Kramer, S
;
Whiteley, GR
;
Wall, MR
;
Mannion, DP
;
Della Cioppa, G
;
Rakitan, JS
;
Wolfe, GM
.
CLINICAL CHEMISTRY,
2005, 51 (10)
:1946-1954

Lopez, MF
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Mikulskis, A
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Kuzdzal, S
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Bennett, DA
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Kelly, J
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Golenko, E
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

DiCesare, J
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Denoyer, E
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Patton, WF
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Ediger, R
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Sapp, L
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Ziegert, T
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Lynch, C
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Kramer, S
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Whiteley, GR
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Wall, MR
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Mannion, DP
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Della Cioppa, G
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Rakitan, JS
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA

Wolfe, GM
论文数: 0 引用数: 0
h-index: 0
机构: PerkinElmer Life & Analyt Sci, Boston, MA 02118 USA
[16]
Analysis of albumin-associated peptides and proteins from ovarian cancer patients
[J].
Lowenthal, MS
;
Mehta, AI
;
Frogale, K
;
Bandle, RW
;
Araujo, RP
;
Hood, BL
;
Veenstra, TD
;
Conrads, TP
;
Goldsmith, P
;
Fishman, D
;
Petricoin, EF III
;
Liotta, LA
.
CLINICAL CHEMISTRY,
2005, 51 (10)
:1933-1945

Lowenthal, MS
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Mehta, AI
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Frogale, K
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Bandle, RW
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Araujo, RP
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Hood, BL
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Veenstra, TD
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Conrads, TP
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Goldsmith, P
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Fishman, D
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Petricoin, EF III
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA

Liotta, LA
论文数: 0 引用数: 0
h-index: 0
机构: George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20110 USA
[17]
Diagnostic proteomics: Back to basics?
[J].
Master, SR
.
CLINICAL CHEMISTRY,
2005, 51 (08)
:1333-1334

Master, SR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[18]
Developing the next generation of cardiac markers: Disease-induced modifications of Troponin I
[J].
McDonough, JL
;
Van Eyk, JE
.
PROGRESS IN CARDIOVASCULAR DISEASES,
2004, 47 (03)
:207-216

McDonough, JL
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Dept Med, Baltimore, MD 21224 USA

Van Eyk, JE
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Univ, Dept Med, Baltimore, MD 21224 USA
[19]
Proteomics and diabetic nephropathy
[J].
Merchant M.L.
;
Klein J.B.
.
Current Diabetes Reports,
2005, 5 (6)
:464-469

Merchant M.L.
论文数: 0 引用数: 0
h-index: 0
机构:
Core Proteomics Laboratory, University of Louisville, Louisville, KY 40202 Core Proteomics Laboratory, University of Louisville, Louisville, KY 40202

Klein J.B.
论文数: 0 引用数: 0
h-index: 0
机构:
Core Proteomics Laboratory, University of Louisville, Louisville, KY 40202 Core Proteomics Laboratory, University of Louisville, Louisville, KY 40202
[20]
Overview of the HUPO Plasma Proteome Project: Results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database
[J].
Omenn, GS
;
States, DJ
;
Adamski, M
;
Blackwell, TW
;
Menon, R
;
Hermjakob, H
;
Apweiler, R
;
Haab, BB
;
Simpson, RJ
;
Eddes, JS
;
Kapp, EA
;
Moritz, RL
;
Chan, DW
;
Rai, AJ
;
Admon, A
;
Aebersold, R
;
Eng, J
;
Hancock, WS
;
Hefta, SA
;
Meyer, H
;
Paik, YK
;
Yoo, JS
;
Ping, PP
;
Pounds, J
;
Adkins, J
;
Qian, XH
;
Wang, R
;
Wasinger, V
;
Wu, CY
;
Zhao, XH
;
Zeng, R
;
Archakov, A
;
Tsugita, A
;
Beer, I
;
Pandey, A
;
Pisano, M
;
Andrews, P
;
Tammen, H
;
Speicher, DW
;
Hanash, SM
.
PROTEOMICS,
2005, 5 (13)
:3226-3245

Omenn, GS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

States, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Adamski, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Blackwell, TW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Menon, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Hermjakob, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Apweiler, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Haab, BB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Simpson, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Eddes, JS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Kapp, EA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Moritz, RL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Chan, DW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Rai, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Admon, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Aebersold, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Eng, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Hancock, WS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Hefta, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Meyer, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Paik, YK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Yoo, JS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Ping, PP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Pounds, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Adkins, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Qian, XH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Wang, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Wasinger, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Wu, CY
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Zhao, XH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Zeng, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Archakov, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Tsugita, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Beer, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Pandey, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Pisano, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Andrews, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Tammen, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Speicher, DW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA

Hanash, SM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Ann Arbor, MI 48109 USA