Chemokines in myocardial ischemia

被引:120
作者
Frangogiannis, NG
Entman, ML
机构
[1] Baylor Coll Med, Cardiovasc Sci Sect, Methodist Hosp, Houston, TX 77030 USA
[2] Baylor Coll Med, De Bakey Heart Ctr, Houston, TX 77030 USA
关键词
D O I
10.1016/j.tcm.2005.06.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chemokine expression is markedly upregulated in healing myocardial infarcts and may play an important role in regulating leukocyte infiltration and activity and in modulating infarct angiogenesis as well as fibrous tissue deposition. The CC chemokine monocyte chemoattractant protein-1/CCL2 has important effects in infarct healing. Monocyte chemoattractant protein-1-/- mice exhibit reduced macrophage infiltration and activation, suppressed cytokine synthesis, delayed phagocytotic removal of dead cardiomyocytes, diminished myofibroblast accumulation, and decreased ventricular remodeling after myocardial infarction. Monocyte chemoattractant protein-1 may also play an important role in the development of interstitial fibrosis in ischemic noninfarctive cardiomyopathy. CXC chemokines are also induced in healing infarcts. Interleukin-8/CXCL8 may mediate neutrophil recruitment and activation and may promote neovessel formation, whereas induction of the angiostatic and antifibrotic chemokine interferon-gamma-inducible protein-10/CXCL10 may serve to prevent premature wound angiogenesis and fibrous tissue deposition in the infarct, until the injured myocardium has been cleared from dead cells and debris and a fibrin-rich provisional matrix is formed. Understanding of the role of chemokines in myocardial ischemia may result in novel strategies in the treatment of patients with ischemic heart disease.
引用
收藏
页码:163 / 169
页数:7
相关论文
共 53 条
[41]   Bone marrow cells regenerate infarcted myocardium [J].
Orlic, D ;
Kajstura, J ;
Chimenti, S ;
Jakoniuk, I ;
Anderson, SM ;
Li, BS ;
Pickel, J ;
McKay, R ;
Nadal-Ginard, B ;
Bodine, DM ;
Leri, A ;
Anversa, P .
NATURE, 2001, 410 (6829) :701-705
[42]   Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4 [J].
Peled, A ;
Petit, I ;
Kollet, O ;
Magid, M ;
Ponomaryov, T ;
Byk, T ;
Nagler, A ;
Ben-Hur, H ;
Many, A ;
Shultz, L ;
Lider, O ;
Alon, R ;
Zipori, D ;
Lapidot, T .
SCIENCE, 1999, 283 (5403) :845-848
[43]   Cloning and relative expression analysis of rat stromal cell derived factor-1 (SDF-1)1:: SDF-1 α mRNA is selectively induced in rat model of myocardial infarction [J].
Pillarisetti, K ;
Gupta, SK .
INFLAMMATION, 2001, 25 (05) :293-300
[44]   Chemokines [J].
Rollins, BJ .
BLOOD, 1997, 90 (03) :909-928
[45]   Monocyte chemoattractant protein 1 a potential regulator of monocyte recruitment in inflammatory disease [J].
Rollins, BJ .
MOLECULAR MEDICINE TODAY, 1996, 2 (05) :198-204
[46]   Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression [J].
Salcedo, R ;
Ponce, ML ;
Young, HA ;
Wasserman, K ;
Ward, JM ;
Kleinman, HK ;
Oppenheim, JJ ;
Murphy, WJ .
BLOOD, 2000, 96 (01) :34-40
[47]   Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1 [J].
Salvucci, O ;
Yao, L ;
Villalba, S ;
Sajewicz, A ;
Pittaluga, S ;
Tosato, G .
BLOOD, 2002, 99 (08) :2703-2711
[48]  
Shiraha H, 1999, J CELL BIOL, V146, P243
[49]   ROLE OF C-X-C CHEMOKINES AS REGULATORS OF ANGIOGENESIS IN LUNG-CANCER [J].
STRIETER, RM ;
POLVERINI, PJ ;
ARENBERG, DA ;
WALZ, A ;
OPDENAKKER, G ;
VANDAMME, J ;
KUNKEL, SL .
JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 57 (05) :752-762
[50]   THE FUNCTIONAL-ROLE OF THE ELR MOTIF IN CXC CHEMOKINE-MEDIATED ANGIOGENESIS [J].
STRIETER, RM ;
POLVERINI, PJ ;
KUNKEL, SL ;
ARENBERG, DA ;
BURDICK, MD ;
KASPER, J ;
DZUIBA, J ;
VANDAMME, J ;
WALZ, A ;
MARRIOTT, D ;
CHAN, SY ;
ROCZNIAK, S ;
SHANAFELT, AB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :27348-27357