Flavonoids: Cellular and molecular mechanism of action in glucose homeostasis

被引：76

作者：

Cazarolli, Luisa Helena ^{[1
]}

Zanatta, Leila ^{[1
]}

Alberton, Elga Heloisa ^{[1
]}

Reis Bonorino Figueiredo, Maria Santos ^{[1
]}

Folador, Poliane ^{[1
]}

Damazio, Rosangela Guollo ^{[1
]}

Pizzolatti, Moacir Geraldo ^{[2
]}

Mena Barreto Silva, Fatima Regina ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Bioquim, BR-88040970 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 10期

关键词：

flavonoids; mechanism of action; glycemia; insulin; diabetes;

D O I：

10.2174/138955708785740580

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The purpose of this review is to discuss the cellular and molecular mechanisms of action of flavonoids focusing on carbohydrate metabolism. The beneficial effects of flavonoids have been studied in relation to diabetes mellitus, either through their capacity to avoid glucose absorption or to improve glucose tolerance. Furthermore, flavonoids stimulate glucose uptake in peripheral tissues, regulate the activity and/or expression of the rate-limiting enzymes in the carbohydrate metabolism pathway and act per se as insulin secretagogues or insulin mimetics, probably, by influencing the pleiotropic mechanisms of insulin signaling, to ameliorate the diabetes status.

引用

页码：1032 / 1038

页数：7

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