Antivirals Targeting Influenza A Virus

被引：89

作者：

Das, Kalyan ^{[1
]}

机构：

[1] Rutgers State Univ, Ctr Adv Biotechnol & Med, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 14期

关键词：

M2 PROTON CHANNELS; STRUCTURAL BASIS; RNA-POLYMERASE; ACTIVE-SITE; IN-VITRO; NEURAMINIDASE INHIBITORS; CRYSTAL-STRUCTURE; CAP-BINDING; ION-CHANNEL; AMINO-ACID;

D O I：

10.1021/jm300455c

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：6263 / 6277

页数：15

共 152 条

[71] Identification of influenza A nucleoprotein as an antiviral target [J].

Kao, Richard Y. ;

Yang, Dan ;

Lau, Lai-Shan ;

Tsui, Wayne H. W. ;

Hu, Lihong ;

Dai, Jun ;

Chan, Mei-Po ;

Chan, Che-Man ;

Wang, Pui ;

Zheng, Bo-Jian ;

Sun, Jian ;

Huang, Jian-Dong ;

Madar, Jason ;

Chen, Guanhua ;

Chen, Honglin ;

Guan, Yi ;

Yuen, Kwok-Yung .

NATURE BIOTECHNOLOGY, 2010, 28 (06) :600-U88

[72] Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity [J].

Kim, CU ;

Lew, W ;

Williams, MA ;

Liu, HT ;

Zhang, LJ ;

Swaminathan, S ;

Bischofberger, N ;

Chen, MS ;

Mendel, DB ;

Tai, CY ;

Laver, WG ;

Stevens, RC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (04) :681-690

[73] T-705 (favipiravir) activity against lethal H5N1 influenza A viruses [J].

Kiso, Maki ;

Takahashi, Kazumi ;

Sakai-Tagawa, Yuko ;

Shinya, Kyoko ;

Sakabe, Saori ;

Le, Quynh Mai ;

Ozawa, Makoto ;

Furuta, Yousuke ;

Kawaoka, Yoshihiro .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (02) :882-887

[74] GROWTH IMPAIRMENT RESULTING FROM EXPRESSION OF INFLUENZA-VIRUS M2 PROTEIN IN SACCHAROMYCES-CEREVISIAE - IDENTIFICATION OF A NOVEL INHIBITOR OF INFLUENZA-VIRUS [J].

KURTZ, S ;

LUO, GX ;

HAHNENBERGER, KM ;

BROOKS, C ;

GECHA, O ;

INGALLS, K ;

NUMATA, KI ;

KRYSTAL, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (10) :2204-2209

[75] SEQUENCES OF MESSENGER-RNAS DERIVED FROM GENOME RNA SEGMENT 7 OF INFLUENZA-VIRUS - COLINEAR AND INTERRUPTED MESSENGER-RNAS CODE FOR OVERLAPPING PROTEINS [J].

LAMB, RA ;

LAI, CJ ;

CHOPPIN, PW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (07) :4170-4174

[76] SITE-DIRECTED MUTATION OF THE ACTIVE-SITE OF INFLUENZA NEURAMINIDASE AND IMPLICATIONS FOR THE CATALYTIC MECHANISM [J].

LENTZ, MR ;

WEBSTER, RG ;

AIR, GM .

BIOCHEMISTRY, 1987, 26 (17) :5351-5358

[77] The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase [J].

Leyssen, P ;

Balzarini, J ;

De Clercq, E ;

Neyts, J .

JOURNAL OF VIROLOGY, 2005, 79 (03) :1943-1947

[78] Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein [J].

Liu, JS ;

Lynch, PA ;

Chien, CY ;

Montelione, GT ;

Krug, RM ;

Berman, HM .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (11) :896-899

[79] NUCLEAR TRANSPORT OF INFLUENZA-VIRUS RIBONUCLEOPROTEINS - THE VIRAL MATRIX PROTEIN (M1) PROMOTES EXPORT AND INHIBITS IMPORT [J].

MARTIN, K ;

HELENIUS, A .

CELL, 1991, 67 (01) :117-130

[80] The Effects of Influenza A Virus PB1-F2 Protein on Polymerase Activity Are Strain Specific and Do Not Impact Pathogenesis [J].

McAuley, Julie L. ;

Zhang, Kelly ;

McCullers, Jonathan A. .

JOURNAL OF VIROLOGY, 2010, 84 (01) :558-564

← 3 4 5 6 7 8 9 10 11 12 →