Naphthalimide hydroperoxides as photonucleases: substituent effects and structural basis

被引：77

作者：

Tao, ZF ^{[1
]}

Qian, XH ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Inst Pesticides & Pharmaceut, Shanghai 200237, Peoples R China

来源：

DYES AND PIGMENTS | 1999年 / 43卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DNA cleaver; DNA intercalator; naphthalimide; peroxides; X-ray single crystal structure; hydroxyl radicals;

D O I：

10.1016/S0143-7208(99)00037-6

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A variety of naphthalimide hydroperoxides as novel photochemical DNA cleavers were synthesized and evaluated. Their photochemical DNA-cleaving abilities depend on the substituents on the aromatic moiety. The DNA-cleaving differences of these hydroperoxides may result from the differences of the intercalating ability of the naphthalene moiety. X-ray single crystal structure of a representative compound 1 was determined, and showed that all endocyclic atoms were coplanar, indicating a structural basis for potential and efficient DNA intercalation by 1. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：139 / 145

页数：7

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