Caspases: Keys in the ignition of cell death

被引：268

作者：

Denault, JB ^{[1
]}

Salvesen, GS ^{[1
]}

机构：

[1] Burnham Inst, Program Apoptosis & Cell Death Res, La Jolla, CA 92037 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr010183n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Caspases:... Current knowledge of the biology of caspases clearly identifies them as prime targets for therapeutics. In principle, inhibition of caspases could deliver therapy in acute cellular degenerative diseases. On the other hand, activation of caspases could be used as a way to therapeutically delete cells in proliferative diseases such as cancer.

引用

页码：4489 / 4499

页数：11

共 88 条

[31] IDENTIFICATION OF A MONOCYTE SPECIFIC PRE-INTERLEUKIN 1-BETA CONVERTASE ACTIVITY
KOSTURA, MJ
TOCCI, MJ
LIMJUCO, G
CHIN, J
CAMERON, P
HILLMAN, AG
CHARTRAIN, NA
SCHMIDT, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) : 5227 - 5231
[32] Quantitative characterization of furin specificity - Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides
Krysan, DJ
Rockwell, NC
Fuller, RS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (33) : 23229 - 23234
[33] Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking Caspase 9
Kuida, K
Haydar, TF
Kuan, CY
Gu, Y
Taya, C
Karasuyama, H
Su, MSS
Rakic, P
Flavell, RA
[J]. CELL, 1998, 94 (03) : 325 - 337
[34] Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K
Zheng, TS
Na, SQ
Kuan, CY
Yang, D
Karasuyama, H
Rakic, P
Flavell, RA
[J]. NATURE, 1996, 384 (6607) : 368 - 372
[35] ALTERED CYTOKINE EXPORT AND APOPTOSIS IN MICE DEFICIENT IN INTERLEUKIN-1-BETA CONVERTING-ENZYME
KUIDA, K
LIPPKE, JA
KU, G
HARDING, MW
LIVINGSTON, DJ
SU, MSS
FLAVELL, RA
[J]. SCIENCE, 1995, 267 (5206) : 2000 - 2003
[36] Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis
Lane, JD
Lucocq, J
Pryde, J
Barr, F
Woodman, PG
Allan, VJ
Lowe, M
[J]. JOURNAL OF CELL BIOLOGY, 2002, 156 (03) : 495 - 509
[37] STUDIES OF THE LAMIN PROTEINASE REVEAL MULTIPLE PARALLEL BIOCHEMICAL PATHWAYS DURING APOPTOTIC EXECUTION
LAZEBNIK, YA
TAKAHASHI, A
MOIR, RD
GOLDMAN, RD
POIRIER, GG
KAUFMANN, SH
EARNSHAW, WC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) : 9042 - 9046
[38] CLEAVAGE OF POLY(ADP-RIBOSE) POLYMERASE BY A PROTEINASE WITH PROPERTIES LIKE ICE
LAZEBNIK, YA
KAUFMANN, SH
DESNOYERS, S
POIRIER, GG
EARNSHAW, WC
[J]. NATURE, 1994, 371 (6495) : 346 - 347
[39] Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
Li, HL
Zhu, H
Xu, CJ
Yuan, JY
[J]. CELL, 1998, 94 (04) : 491 - 501
[40] MICE DEFICIENT IN IL-1-BETA-CONVERTING ENZYME ARE DEFECTIVE IN PRODUCTION OF MATURE IL-1-BETA AND RESISTANT TO ENDOTOXIC-SHOCK
LI, P
ALLEN, H
BANERJEE, S
FRANKLIN, S
HERZOG, L
JOHNSTON, C
MCDOWELL, J
PASKIND, M
RODMAN, L
SALFELD, J
TOWNE, E
TRACEY, D
WARDWELL, S
WEI, FY
WONG, W
KAMEN, R
SESHADRI, T
[J]. CELL, 1995, 80 (03) : 401 - 411

← 1 2 3 4 5 6 7 8 9 →