Does everything now make (anti)sense?

被引：25

作者：

Timmons, J. A.

Good, L.

机构：

[1] Karolinska Inst, Programme Genom & Bioinformat, SE-17177 Stockholm, Sweden

[2] Heriot Watt Univ, Sch Life Sci, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

biodiversity; epigenetics; imprinting; natural antisense; non-coding RNA; transcription;

D O I：

10.1042/BST0341148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The data generated by the FANTOM (Functional Annotation of mouse) consortium, Compugen and Affymetrix have collectively provided evidence that most of the mammalian genomes are actively transcribed. The emergence of an antisense RNA world brings new practical complexities to the study and detection of gene expression. However, we also need to address the fundamental questions regarding the functional importance of these molecules. in this brief paper, we focus on non-coding natural antisense transcription, as it appears to be a potentially powerful mechanism for extending the complexity of the protein coding genome, which is currently unable to explain inter-species diversification.

引用

页码：1148 / 1150

页数：3

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