Studies on pyrrolidinones:: Some attempts to improve the synthesis of methyl N-(3,4,4′,5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) by using N-acyl iminium salts methodologies.

被引：6

作者：

Bourry, A

Pitard, F

Rigo, B

Sanz, G

Camus, F

Norberg, B

Durant, F

Couturier, D

机构：

[1] Ecole Hautes Etud Ind, Grp Rech Inhibit Proliferat Cellulaire, F-59046 Lille, France

[2] Janssen Res Fdn, F-27106 Val De Reuil, France

[3] Fac Univ Notre Dame Paix, Lab Chim Mol Struct, B-5000 Namur, Belgium

[4] Univ Sci & Technol, Lab Ingn Mol, F-59655 Villeneuve Dascq, France

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2002年 / 39卷 / 01期

关键词：

D O I：

10.1002/jhet.5570390116

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some ways to use the N-acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N-(3,4,4',5-tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3-(3,4,5-trimethoxyphenyl)dihydropyrrolo[1,2-c]oxazole-1,5-dione).

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页码：109 / 118

页数：10

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