NFAT and NF-κB factors -: the distant relatives

被引：60

作者：

Serfling, E

Berberich-Siebelt, F

Avots, A

Chuvpilo, S

Klein-Hessling, S

Jha, MK

Kondo, E

Pagel, P

Schulze-Luehrmann, J

Palmetshofer, A

机构：

[1] Univ Wurzburg, Inst Pathol, Dept Mol Pathol, D-97080 Wurzburg, Germany

[2] Okayama Univ, Grad Sch Med & Dent, Dept Pathol, Okayama, Japan

[3] GSF, Natl Res Ctr Environm & Hlth, Inst Bioinformat, MIPS, D-85764 Neuherberg, Germany

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 07期

关键词：

apoptosis; evolution; immunity; NEAT; NF-kappa B;

D O I：

10.1016/j.biocel.2003.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NFAT and NF-kappaB proteins are members of a superfamily of transcription factors whose activity plays a crucial role in the activation, proliferation and apoptosis of lymphocytes. Both types of factors share a number of properties, including similar DNA binding domains and rapid nuclear translocation upon antigenic stimulation. While NF-kappaBs control both innate and adaptive immune responses, NFATs control the adaptive immune system which emerged-in parallel with the appearance of the NFAT family-in jawed fish. However, NFATs and NF-kappaBs differ remarkably in their function. Whereas NFATs support activation-induced cell death (AICD) of T and B cells, NF-kappaB proteins frequently exert a strong anti-apoptotic effect on lymphocytes and other cells. While the anti-apoptotic activity of NF-kappaBs contributes to their oncogenic capacity, the pro-apoptotic activity favors NFATs as tumor suppressors in lymphoid cells. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1166 / 1170

页数：5

共 20 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2] Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes [J].

Aparicio, S ;

Chapman, J ;

Stupka, E ;

Putnam, N ;

Chia, J ;

Dehal, P ;

Christoffels, A ;

Rash, S ;

Hoon, S ;

Smit, A ;

Gelpke, MDS ;

Roach, J ;

Oh, T ;

Ho, IY ;

Wong, M ;

Detter, C ;

Verhoef, F ;

Predki, P ;

Tay, A ;

Lucas, S ;

Richardson, P ;

Smith, SF ;

Clark, MS ;

Edwards, YJK ;

Doggett, N ;

Zharkikh, A ;

Tavtigian, SV ;

Pruss, D ;

Barnstead, M ;

Evans, C ;

Baden, H ;

Powell, J ;

Glusman, G ;

Rowen, L ;

Hood, L ;

Tan, YH ;

Elgar, G ;

Hawkins, T ;

Venkatesh, B ;

Rokhsar, D ;

Brenner, S .

SCIENCE, 2002, 297 (5585) :1301-1310

[3] NFATc2-mediated repression of cyclin-dependent kinase 4 expression [J].

Baksh, S ;

Widlund, HR ;

Frazer-Abel, AA ;

Du, JY ;

Fosmire, S ;

Fisher, DE ;

DeCaprio, JA ;

Modiano, JF ;

Burakoff, SJ .

MOLECULAR CELL, 2002, 10 (05) :1071-1081

[4] Structure of the DNA binding domains from NFAT, Fos and Jun bound specifically to DNA [J].

Chen, L ;

Glover, JNM ;

Hogan, PG ;

Rao, A ;

Harrison, SC .

NATURE, 1998, 392 (6671) :42-48

[5] Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis [J].

Chuvpilo, S ;

Jankevics, E ;

Tyrsin, D ;

Akimzhanov, A ;

Moroz, D ;

Jha, MK ;

Luehrmann, JS ;

Santner-Nanan, B ;

Feoktistova, E ;

König, T ;

Avots, A ;

Schmitt, E ;

Berberich-Siebelt, F ;

Schimpl, A ;

Serfling, E .

IMMUNITY, 2002, 16 (06) :881-895

[6] NFAT signaling: Choreographing the social lives of cells [J].

Crabtree, GR ;

Olson, EN .

CELL, 2002, 109 :S67-S79

[7] The draft genome of Ciona intestinalis:: Insights into chordate and vertebrate origins [J].

Dehal, P ;

Satou, Y ;

Campbell, RK ;

Chapman, J ;

Degnan, B ;

De Tomaso, A ;

Davidson, B ;

Di Gregorio, A ;

Gelpke, M ;

Goodstein, DM ;

Harafuji, N ;

Hastings, KEM ;

Ho, I ;

Hotta, K ;

Huang, W ;

Kawashima, T ;

Lemaire, P ;

Martinez, D ;

Meinertzhagen, IA ;

Necula, S ;

Nonaka, M ;

Putnam, N ;

Rash, S ;

Saiga, H ;

Satake, M ;

Terry, A ;

Yamada, L ;

Wang, HG ;

Awazu, S ;

Azumi, K ;

Boore, J ;

Branno, M ;

Chin-bow, S ;

DeSantis, R ;

Doyle, S ;

Francino, P ;

Keys, DN ;

Haga, S ;

Hayashi, H ;

Hino, K ;

Imai, KS ;

Inaba, K ;

Kano, S ;

Kobayashi, K ;

Kobayashi, M ;

Lee, BI ;

Makabe, KW ;

Manohar, C ;

Matassi, G ;

Medina, M .

SCIENCE, 2002, 298 (5601) :2157-2167

[8] NF-κB and rel proteins:: Evolutionarily conserved mediators of immune responses [J].

Ghosh, S ;

May, MJ ;

Kopp, EB .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :225-260

[9] Missing pieces in the NF-κB puzzle [J].

Ghosh, S ;

Karin, M .

CELL, 2002, 109 :S81-S96

[10] Evolutionary relationships among Rel domains indicate functional diversification by recombination [J].

Graef, IA ;

Gastier, JM ;

Francke, U ;

Crabtree, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (10) :5740-5745

← 1 2 →