MicroRNAs: Target Recognition and Regulatory Functions

被引：16307

作者：

Bartel, David P. ^{[1
,2
,3
]}

机构：

[1] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

CELL | 2009年 / 136卷 / 02期

基金：

美国国家卫生研究院;

关键词：

UTR SEQUENCE MOTIF; POSTTRANSCRIPTIONAL REGULATION; MESSENGER-RNAS; C-ELEGANS; GENE-EXPRESSION; BINDING-SITES; K-BOX; LET-7; ACTIVATION; DIFFERENTIATION;

D O I：

10.1016/j.cell.2009.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are endogenous 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.

引用

页码：215 / 233

页数：19

共 112 条

[11] Identification of human microRNA targets from isolated argonaute protein complexes
Beitzinger, Michaela
Peters, Lasse
Zhu, Jia Yun
Kremmer, Elisabeth
Meister, Gunter
[J]. RNA BIOLOGY, 2007, 4 (02) : 76 - 84
[12] The microRNA.org resource: targets and expression
Betel, Doron
Wilson, Manda
Gabow, Aaron
Marks, Debora S.
Sander, Chris
[J]. NUCLEIC ACIDS RESEARCH, 2008, 36 : D149 - D153
[13] Relief of microRNA-mediated translational repression in human cells subjected to stress
Bhattacharyya, Suvendra N.
Habermacher, Regula
Martine, Ursula
Closs, Ellen I.
Filipowicz, Witold
[J]. CELL, 2006, 125 (06) : 1111 - 1124
[14] Principles of MicroRNA-target recognition
Brennecke, J
Stark, A
Russell, RB
Cohen, SM
[J]. PLOS BIOLOGY, 2005, 3 (03): : 404 - 418
[15] Target protectors reveal dampening and balancing of nodal agonist and antagonist by miR-430
Choi, Wen-Yee
Giraldez, Antonio J.
Schier, Alexander F.
[J]. SCIENCE, 2007, 318 (5848) : 271 - 274
[16] A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
Clop, Alex
Marcq, Fabienne
Takeda, Haruko
Pirottin, Dimitri
Tordoir, Xavier
Bibe, Bernard
Bouix, Jacques
Caiment, Florian
Elsen, Jean-Michel
Eychenne, Francis
Larzul, Catherine
Laville, Elisabeth
Meish, Francoise
Milenkovic, Dragan
Tobin, James
Charlier, Carole
Georges, Michel
[J]. NATURE GENETICS, 2006, 38 (07) : 813 - 818
[17] Denoising feedback loops by thresholding - a new role for microRNAs
Cohen, Stephen M.
Brennecke, Julius
Stark, Alexander
[J]. GENES & DEVELOPMENT, 2006, 20 (20) : 2769 - 2772
[18] RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus
Davis, E
Caiment, F
Tordoir, X
Cavaillé, J
Ferguson-Smith, A
Cockett, N
Georges, M
Charlier, C
[J]. CURRENT BIOLOGY, 2005, 15 (08) : 743 - 749
[19] Molecular architecture of a miRNA-regulated 3′ UTR
Didiano, Dominic
Hobert, Oliver
[J]. RNA, 2008, 14 (07) : 1297 - 1317
[20] Specificity of microRNA target selection in translational repression
Doench, JG
Sharp, PA
[J]. GENES & DEVELOPMENT, 2004, 18 (05) : 504 - 511

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