Allogeneic hematopoietic stem cell transplantation in children with sickle cell disease

被引：33

作者：

Locatelli, Franco ^{[1
,2
]}

Pagliara, Daria ^{[1
]}

机构：

[1] Univ Pavia, IRCCS Osped Pediat Bambino Gesu, Dipartimento Ematol & Oncol Pediat, I-00165 Rome, Italy

[2] Univ Pavia, I-27100 Pavia, Italy

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 02期

关键词：

allogeneic hematopoietic stem cell transplantation; cord blood transplantation; mixed chimerism; sickle cell disease; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; VERSUS-HOST-DISEASE; SEVERE APLASTIC-ANEMIA; BETA-THALASSEMIA; MIXED CHIMERISM; DONOR TRANSPLANTATION; RANDOMIZED-TRIAL; HYDROXYUREA; PATIENT;

D O I：

10.1002/pbc.24177

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment for sickle cell disease (SCD), being successful in around 8590% of patients. Mortality and long-term morbidity (including infertility, gonadal failure, and chronic graft-vs.-host disease) associated with conventional approaches curtail the number of patients who undergo allo-HSCT. Recently, it has been demonstrated that cord blood is as effective as and possibly safer than bone marrow in pediatric patients with SCD. Likewise, transplant strategies based on the use of reduced-intensity regimens and the induction of mixed chimerism have been explored to decrease allo-HSCT short- and long-term complications. Pediatr Blood Cancer 2012;59:372376. (c) 2012 Wiley Periodicals, Inc.

引用

页码：372 / 376

页数：5

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