Small-molecule inhibitors of microRNA miR-21 function

被引：344

作者：

Gumireddy, Kiranmai ^{[1
]}

Young, Douglas D. ^{[2
]}

Xiong, Xin ^{[2
]}

Hogenesch, John B. ^{[3
]}

Huang, Qihong ^{[1
]}

Deiters, Alexander ^{[2
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[2] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

[3] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 39期

基金：

美国国家卫生研究院;

关键词：

antitumor agents; cell-based assays; inhibitors; medicinal chemistry; microRNA;

D O I：

10.1002/anie.200801555

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Short, but significant, microRNAs (miRNAs) are an important class of gene regulators. Small-molecule modifiers of miRNA function, such as 1 (see schematic representation), were identified in a cellular screen for miRNA-pathway inhibitors. Such compounds are expected to be useful tools for the elucidation of detailed mechanisms of miRNA action and may serve as lead structures for the development of new therapeutic agents. (Chemical Equation Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7482 / 7484

页数：3

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