Biopsy with Thermally-Responsive Untethered Microtools

被引:221
作者
Gultepe, Evin [1 ]
Randhawa, Jatinder S. [1 ]
Kadam, Sachin [1 ]
Yamanaka, Sumitaka [2 ]
Selaru, Florin M. [2 ]
Shin, Eun J. [2 ]
Kalloo, Anthony N. [2 ]
Gracias, David H. [1 ,3 ]
机构
[1] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Dept Med, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA
基金
美国国家科学基金会;
关键词
actuators; stimuli responsive materials; robotics; self-assembly; self-folding; microsurgery;
D O I
10.1002/adma.201203348
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Thermally activated, untethered microgrippers can reach narrow conduits in the body and be used to excise tissue for diagnostic analyses. As depicted in the figure, the feasibility of an in vivo biopsy of the porcine bile duct using untethered microgrippers is demonstrated.
引用
收藏
页码:514 / 519
页数:6
相关论文
共 52 条
[41]   Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays [J].
Selaru, FM ;
Zou, T ;
Xu, Y ;
Shustova, V ;
Yin, J ;
Mori, Y ;
Sato, F ;
Wang, S ;
Olaru, A ;
Shibata, D ;
Greenwald, BD ;
Krasna, MJ ;
Abraham, JM ;
Meltzer, SJ .
ONCOGENE, 2002, 21 (03) :475-478
[42]   Fantastic Voyage: Designing Self-Powered Nanorobots [J].
Sengupta, Samudra ;
Ibele, Michael E. ;
Sen, Ayusman .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (34) :8434-8445
[43]   Self-Propelled Nanotools [J].
Solovev, Alexander A. ;
Xi, Wang ;
Gracias, David H. ;
Harazim, Stefan M. ;
Deneke, Christoph ;
Sanchez, Samuel ;
Schmidt, Oliver G. .
ACS NANO, 2012, 6 (02) :1751-1756
[44]   Exploring the Genomes of Cancer Cells: Progress and Promise [J].
Stratton, Michael R. .
SCIENCE, 2011, 331 (6024) :1553-1558
[45]   Developing essential tools to enable transgastric surgery [J].
Swanstrom, L. L. ;
Whiteford, M. ;
Khajanchee, Y. .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2008, 22 (03) :600-604
[46]   Magnetic Helical Micromachines: Fabrication, Controlled Swimming, and Cargo Transport [J].
Tottori, Soichiro ;
Zhang, Li ;
Qiu, Famin ;
Krawczyk, Krzysztof K. ;
Franco-Obregon, Alfredo ;
Nelson, Bradley J. .
ADVANCED MATERIALS, 2012, 24 (06) :811-816
[47]  
Tumbleson M. E., 1996, ADV SWINE BIOMEDICAL, V1
[48]   Self-Assembly Based on Chromium/Copper Bilayers [J].
Tyagi, Pawan ;
Bassik, Noy ;
Leong, Timothy G. ;
Cho, Jeong-Hyun ;
Benson, Bryan R. ;
Gracias, David H. .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2009, 18 (04) :784-791
[49]   Valley-fold and mountain-fold in the micro-origami technique [J].
Vaccaro, PO ;
Kubota, K ;
Fleischmann, T ;
Saravanan, S ;
Aida, T .
MICROELECTRONICS JOURNAL, 2003, 34 (5-8) :447-449
[50]   Nano/Microscale Motors: Biomedical Opportunities and Challenges [J].
Wang, Joseph ;
Gao, Wei .
ACS NANO, 2012, 6 (07) :5745-5751