Functional Analysis of Insertion Sequence ISAba1, Responsible for Genomic Plasticity of Acinetobacter baumannii

被引：118

作者：

Mugnier, Pauline D.

Poirel, Laurent

Nordmann, Patrice ^{[1
]}

机构：

[1] Hop Bicetre, AP HP, INSERM, Serv Bacteriol Virol,Emerging Resistance Antibiot, F-94275 Le Kremlin Bicetre, France

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 07期

关键词：

SPECTRUM BETA-LACTAMASE; CLAVULANIC ACID; EXPRESSION; TRANSPOSITION; MOBILIZATION; INSTABILITY; BLA(CTX-M); ELEMENTS; REGION; GENES;

D O I：

10.1128/JB.01258-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

ISAba1 is an insertion sequence that is widely distributed in Acinetobacter baumannii. We demonstrated here that ISAba1 and the composite transposon Tn2006 are capable of transposition, generating 9-bp target site duplications. The expression of the ISAba1 transposase-encoding gene was downregulated by translational frameshifting.

引用

页码：2414 / 2418

页数：5

共 34 条

[1] Comparative Genome Sequence Analysis of Multidrug-Resistant Acinetobacter baumannii [J].

Adams, Mark D. ;

Goglin, Karrie ;

Molyneaux, Neil ;

Hujer, Kristine M. ;

Lavender, Heather ;

Jamison, Jennifer J. ;

MacDonald, Ian J. ;

Martin, Kristienna M. ;

Russo, Thomas ;

Campagnari, Anthony A. ;

Hujer, Andrea M. ;

Bonomo, Robert A. ;

Gill, Steven R. .

JOURNAL OF BACTERIOLOGY, 2008, 190 (24) :8053-8064

[2] Functional characterization of IS1999, an IS4 family element involved in mobilization and expression of β-lactam resistance genes [J].

Aubert, Daniel ;

Naas, Thierry ;

Heritier, Claire ;

Poirel, Laurent ;

Nordmann, Patrice .

JOURNAL OF BACTERIOLOGY, 2006, 188 (18) :6506-6514

[3] SOS response promotes horizontal dissemination of antibiotic resistance genes [J].

Beaber, JW ;

Hochhut, B ;

Waldor, MK .

NATURE, 2004, 427 (6969) :72-74

[4] TRANSLATIONAL FRAMESHIFTING IN THE CONTROL OF TRANSPOSITION IN BACTERIA [J].

CHANDLER, M ;

FAYET, O .

MOLECULAR MICROBIOLOGY, 1993, 7 (04) :497-503

[5]

Chandler M., 2002, Mobile DNA II, P305, DOI DOI 10.1128/9781555817954.CH15

[6] AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains [J].

Corvec, S ;

Caroff, N ;

Espaze, E ;

Giraudeau, C ;

Drugeon, H ;

Reynaud, A .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (04) :629-635

[7] Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii [J].

Corvec, Stephane ;

Poirel, Laurent ;

Naas, Thierry ;

Drugeon, Henri ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (04) :1530-1533

[8] GENETIC-ANALYSIS OF THE INTERACTION OF THE INSERTION-SEQUENCE IS903 TRANSPOSASE WITH ITS TERMINAL INVERTED REPEATS [J].

DERBYSHIRE, KM ;

HWANG, L ;

GRINDLEY, NDF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (22) :8049-8053

[9] IS THE IS1 TRANSPOSASE, INSAB', THE ONLY IS1-ENCODED PROTEIN REQUIRED FOR EFFICIENT TRANSPOSITION [J].

ESCOUBAS, JM ;

LANE, D ;

CHANDLER, M .

JOURNAL OF BACTERIOLOGY, 1994, 176 (18) :5864-5867

[10] Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii [J].

Héritier, C ;

Poirel, L ;

Nordmann, P .

CLINICAL MICROBIOLOGY AND INFECTION, 2006, 12 (02) :123-130

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