The resolution of important pharmaceutical building blocks by palladium-catalyzed aerobic oxidation of secondary alcohols

被引：47

作者：

Caspi, DD ^{[1
]}

Ebner, DC ^{[1
]}

Bagdanoff, JT ^{[1
]}

Stoltz, BM ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Arnold & Mabel Beckman Labs Chem Synth, Pasadena, CA 91125 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2004年 / 346卷 / 2-3期

关键词：

asymmetric catalysis; kinetic resolution; oxidation; oxygen; palladium; pharmaceutical substance;

D O I：

10.1002/adsc.200303188

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The palladium-catalyzed aerobic oxidative kinetic resolution of key pharmaceutical building blocks is described. Substrates investigated are relevant to the enantioselective preparation of Prozac((R)), Singulair((R)), and the promising hNK-1 receptor antagonist from Merck. The latter provides the most selective aerobic oxidative kinetic resolution yet described.

引用

页码：185 / 189

页数：5

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