Genome-Wide Association Scan of Attention Deficit Hyperactivity Disorder

被引：188

作者：

Neale, Benjamin M. ^{[1
,2
,3
,4
,5
]}

Lasky-Su, Jessica ^{[2
,6
]}

Anney, Richard ^{[7
]}

Franke, Barbara ^{[8
,9
]}

Zhou, Kaixin ^{[1
]}

Maller, Julian B. ^{[10
]}

Arias Vasquez, Alejandro ^{[8
,9
]}

Asherson, Philip ^{[1
]}

Chen, Wai ^{[1
]}

Banasehewski, Tobias ^{[11
]}

Buitelaar, Jan ^{[8
]}

Ebstein, Richard ^{[12
]}

Gill, Michael ^{[7
]}

Miranda, Ana ^{[13
]}

Oades, Robert D. ^{[14
]}

Roeyers, Herbert ^{[15
]}

Rothenberger, Aribert ^{[16
]}

Sergeant, Joseph ^{[17
]}

Steinhausen, Hans Christoph ^{[18
]}

Sonuga-Barke, Edmund J. S. ^{[1
,19
,20
]}

Mulas, Fernando ^{[21
]}

Taylor, Eric ^{[1
]}

Laird, Nan ^{[22
]}

Lange, Christoph ^{[6
,22
]}

Daly, Mark ^{[3
,4
,5
]}

Faraone, Stephen V. ^{[2
,22
,23
]}

机构：

[1] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London, England

[2] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA

[3] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[4] Broad Inst Harvard, Cambridge, MA USA

[5] MIT, Cambridge, MA 02139 USA

[6] Harvard Univ, Sch Med, Channing Lab, Brigham & Womens Hosp, Boston, MA 02115 USA

[7] St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland

[8] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands

[9] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands

[10] Univ Oxford, Dept Stat, Oxford OX1 3TG, England

[11] Heidelberg Univ, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherpay, D-6800 Mannheim, Germany

[12] Geha MHC, Petah Tiqwa, Israel

[13] Univ Valencia, Dept Dev & Educ Psychol, Valencia, Spain

[14] Univ Clin Child & Adolescent Psychiat, Essen, Germany

[15] Univ Ghent, B-9000 Ghent, Belgium

[16] Univ Gottingen, Gottingen, Germany

[17] Vrije Univ Amsterdam, Amsterdam, Netherlands

[18] Univ Zurich, Dept Child & Adolescent Psychait, Zurich, Switzerland

[19] Univ Southampton, Inst Disorder Impulse & Attent, Sch Psychol, Southampton, Hants, England

[20] NYU, Ctr Child Study, New York, NY USA

[21] La Fe Univ Hosp, Fac Med, Dept Neuropaediat, Valencia, Spain

[22] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[23] SUNY Upstate Med Univ, Dept Neurosci, Syracuse, NY 13210 USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2008年 / 147B卷 / 08期

关键词：

ADHD; genome-wide association; SNP chip; genetic association information network;

D O I：

10.1002/ajmg.b.30866

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Results of behavioral genetic and molecular genetic studies have converged to suggest that genes substantially contribute to the development of attention deficit/hyperactivity disorder (ADHD), a common disorder with an onset in childhood. Yet, despite numerous linkage and candidate gene studies, strongly consistent and replicable association has eluded detection. To search for ADHD susceptibility genes, we genotyped approximately 600,000 SNPs in 958 ADHD affected family trios. After cleaning the data, we analyzed 438,784 SNPs in 2,803 individuals comprising 909 complete trios using ADHD diagnosis as phenotype. We present the initial TDT findings as well as considerations for cleaning family-based TDT data. None of the SNP association tests achieved genome-wide significance, indicating that larger samples may be required to identify risk loci for ADHD. We additionally identify a systemic bias in family-based association, and suggest that variable missing genotype rates may be the source of this bias. (c) 2008 Wiley-Liss, Inc.

引用

页码：1337 / 1344

页数：8

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