The Roles of Neurotrophic Factor and Wnt Signaling in Depression

被引：85

作者：

Voleti, B. ^{[1
]}

Duman, R. S. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Div Mol Psychiat,Abraham Ribicoff Res Facil, New Haven, CT 06508 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 91卷 / 02期

关键词：

GLYCOGEN-SYNTHASE KINASE-3; STRESS; NEUROGENESIS; PATHWAYS; RECEPTOR; CORTEX; BRAIN; MODEL;

D O I：

10.1038/clpt.2011.296

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Depression is a debilitating disease with a lifetime prevalence of similar to 16% in the American population.(1) In addition to the monoamine hypothesis, altered expressions of neurotrophic factors, growth factors, and Wnt signaling are implicated in the pathophysiology and treatment of depression. This review focuses on intracellular signaling cascades that underlie depression and treatment response.

引用

页码：333 / 338

页数：6

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