Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida

被引：209

作者：

Yang, Chen ^{[1
]}

Chung, Donghwa ^{[1
]}

Shina, Il-Shik ^{[1
]}

Lee, HyeonYong ^{[2
,3
]}

Kim, JinChul ^{[2
,3
]}

Lee, YongJin ^{[4
]}

You, SangGuan ^{[1
]}

机构：

[1] Kangnung Natl Univ, Dept Marine Food Sci & Technol, Kangnung 210702, Gangwon, South Korea

[2] Kangwon Natl Univ, Coll Biosci &Biotechnol, Chunchon 200701, Gangwon, South Korea

[3] Kangwon Natl Univ, Res Inst Biosci & Biotechnol, Chunchon 200701, Gangwon, South Korea

[4] Chuncheon Bioind Fdn, Chunchon 200957, Gangwon, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2008年 / 43卷 / 05期

关键词：

Fucoidans; Molecular weight; Anticancer activity; Depolymerization; Undaria pinnatifida;

D O I：

10.1016/j.ijbiomac.2008.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrolyzed fucoidans, from sporophyll of Undaria pinnatifida, were used to determine the effects of molecular weight (M,) and hydrolysis conditions on cancer cell growth. Native fucoidans showed anticancer activity of 37.6%. When hydrolyzed in boiling water with HCl for 5 min, fucoidans (M-w = 490 kDa) significantly increased anticancer activity to 75.9%. However, fucoidans hydrolyzed in a microwave oven showed little improvement of anticancer activity and even exhibited the inhibition activity below 30% when treated more than 90 s. This suggests that anticancer activity of fucoidans could be significantly enhanced by lowering their M, only when they are depolymerized by mild condition. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：433 / 437

页数：5

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