Remarkable phosphodiester hydrolysis activity of a novel CeIV complex in neutral aqueous solutions

被引：20

作者：

Baykal, U ^{[1
]}

Akkaya, MS ^{[1
]}

Akkaya, EU ^{[1
]}

机构：

[1] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 1999年 / 145卷 / 1-2期

关键词：

phosphodiester hydrolysis; artificial enzymes; lanthanide complexes; RNA cleavage;

D O I：

10.1016/S1381-1169(99)00160-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A novel Ce-IV-complex of 1,4,7-tris(carbamoylmethyl)-1,4,7-triazacyclononane has been synthesized. The complex is both stable in aqueous solutions at neutral pH and very efficient in promoting the hydrolysis of a phosphodiester model compound and yeast tRNA(phe). The RNA model compound, 2-hydroxypropyl-p-nitrophenylphosphate hydrolysis is accelerated 7400-fold at pH 7.5, as a result of an unprecedented hydrolytic activity. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：309 / 312

页数：4

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