New approaches in immunotherapy: allergen vaccination with immunostimulatory DNA

被引：25

作者：

Creticos, PS

Chen, YH

Schroeder, JI

机构：

[1] Johns Hopkins Univ, Dept Med, Johns Hopkins Asthma & Allergy Ctr, Div Clin Immunol & Allergy, Baltimore, MD 21224 USA

[2] Paichung Vet Gen Hosp, Taichung 40705, Taiwan

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2004年 / 24卷 / 04期

关键词：

D O I：

10.1016/j.iac.2004.06.012

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Despite its success, conventional immunotherapy is saddled with a number of encumbrances. An allergenic vaccine that could reduce allergenicity, maintain immunogenicity, and be given in a few doses would have important therapeutic implications, as millions of patients with poorly controlled allergic rhinitis and asthma would be candidates for such a form of immunomodulation. This article addresses a specific adjuvant approach to immunotherapy in which highly active immunostimulatory phosphorothioate oligodeoxyribonucleotide moieties are linked to the principal allergenic moiety of a relevant aeroallergen.

引用

页码：569 / +

页数：14

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