Elimination of β-blockers in sewage treatment plants

被引：232

作者：

Maurer, M. ^{[1
]}

Escher, B. I. ^{[1
]}

Richle, P. ^{[1
]}

Schaffner, C. ^{[1
]}

Alder, A. C. ^{[1
]}

机构：

[1] Swiss Fed Inst Aquat Sci & Technol Eawag, CH-8600 Dubendorf, Switzerland

来源：

WATER RESEARCH | 2007年 / 41卷 / 07期

关键词：

wastewater treatment plant; beta-blocker; propranolol; metoprolol; sotalol; atenolol; biodegradation rate; sorption;

D O I：

10.1016/j.watres.2007.01.004

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

beta-Blockers are used to treat high blood pressure as well as patients recovering from heart attacks. In several studies, they were detected in surface water, thus indicating incomplete degradability of these substances in sewage treatment plants (STPs). In this study, we determined the sorption coefficients (K-D) and degradation rates of the four beta-blockers sotalol, atenolol, metoprolol and propranolol in sludge from an STP operating with municipal wastewater. The sorption coefficients (K-D, standard deviations in brackets) were determined as 0.04(+/- 0.03S), 0.04(+/- 0.033), 0.00(+/- 0.023) and 0.32(+/- 0.058) L g(COD)(-1), and the pseudo-first-order degradation rate constants were estimated to be 0.29(+/- 0.02), 0.69(+/- 0.05), 0.58(+/- 0.05) and 0.39(+/- 0.07) L d(-1) g(COD)(-1) for sotalol, atenolol, metoprolol and propranolol, respectively. These values translate into a typical elimination in STPs (sludge concentrations of 4 g(COD) L-1 and a hydraulic retention time of 6h) of 25%, 37%, 44% and 50% for sotalol, propranolol, metoprolol and atenolol, respectively These results are also confirmed by measurements in two municipal STPs for atenolol, sotalol and propranolol. The estimated eliminations are slightly too high for metoprolol. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1614 / 1622

页数：9

共 33 条

[21] Removal of selected non-steroidal anti-inflammatory drugs (NSAIDs), gemfibrozil, carbamazepine, β-blockers, trimethoprim and triclosan in conventional wastewater treatment plants in five EU countries and their discharge to the aquatic environment [J].

Paxéus, N .

WATER SCIENCE AND TECHNOLOGY, 2004, 50 (05) :253-260

[22] METABOLISM OF ATENOLOL IN MAN [J].

REEVES, PR ;

MCAINSH, J ;

MCINTOSH, DAD ;

WINROW, MJ .

XENOBIOTICA, 1978, 8 (05) :313-320

[23] AQUASIM - A TOOL FOR SIMULATION AND DATA-ANALYSIS OF AQUATIC SYSTEMS [J].

REICHERT, P .

WATER SCIENCE AND TECHNOLOGY, 1994, 30 (02) :21-30

[24] The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment [J].

Roberts, PH ;

Thomas, KV .

SCIENCE OF THE TOTAL ENVIRONMENT, 2006, 356 (1-3) :143-153

[25]

Schwarzenbach RP, 2003, ENV ORGANIC CHEM

[26] Liquid chromatography with triple-quadrupole or quadrupole-time of flight mass spectrometry for screening and confirmation of residues of pharmaceuticals in water [J].

Stolker, AAM ;

Niesing, W ;

Hogendoorn, EA ;

Versteegh, JFM ;

Fuchs, R ;

Brinkman, UAT .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2004, 378 (04) :955-963

[27]

Ternes T., 2006, HUMAN PHARM HORMONES, V5, P15, DOI DOI 10.2166/9781780402468

[28] A rapid method to measure the solid-water distribution coefficient (Kd) for pharmaceuticals and musk fragrances in sewage sludge [J].

Ternes, TA ;

Herrmann, N ;

Bonerz, M ;

Knacker, T ;

Siegrist, H ;

Joss, A .

WATER RESEARCH, 2004, 38 (19) :4075-4084

[29] Occurrence of drugs in German sewage treatment plants and rivers [J].

Ternes, TA .

WATER RESEARCH, 1998, 32 (11) :3245-3260

[30] The occurrence of selected human pharmaceutical compounds in UK estuaries [J].

Thomas, KV ;

Hilton, MJ .

MARINE POLLUTION BULLETIN, 2004, 49 (5-6) :436-444

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