Preparation of C8-amine and acetylamine adducts of 2′-deoxyguanosine suitably protected for DNA synthesis

被引：62

作者：

Gillet, LCJ ^{[1
]}

Schärer, OD ^{[1
]}

机构：

[1] Univ Zurich, Inst Med Radiobiol, CH-8008 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 24期

关键词：

D O I：

10.1021/ol026474f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C8-Amine and acetylamine adducts of 2'-deoxyguanosine were synthesized. Our approach provides solutions for the coupling of aromatic amines to a protected 8-bromo-2'-deoxyguanosine derivative, for the selective acetylation of the coupled adduct at N-8 and for a protecting group scheme preserving the integrity of the base-labile N-8 acetyl group during DNA synthesis.

引用

页码：4205 / 4208

页数：4

共 29 条

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