From words to literature in structural proteomics

被引：344

作者：

Sali, A ^{[1
]}

Glaeser, R

Earnest, T

Baumeister, W

机构：

[1] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Calif Inst Quantitat Biomed Res, San Francisco, CA 94143 USA

[4] Univ Calif Berkeley, Dept Mol & Cell Biol, Stanley Donner ASU, Berkeley, CA 94720 USA

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley Ctr Struct Biol, Berkeley, CA 94720 USA

[6] Max Planck Inst Biochem, Dept Biol Struct, D-82152 Martinsried, Germany

来源：

NATURE | 2003年 / 422卷 / 6928期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature01513

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Technical advances on several frontiers have expanded the applicability of existing methods in structural biology and helped close the resolution gaps between them. As a result, we are now poised to integrate structural information gathered at multiple levels of the biological hierarchy - from atoms to cells - into a common framework. The goal is a comprehensive description of the multitude of interactions between molecular entities, which in turn is a prerequisite for the discovery of general structural principles that underlie all cellular processes.

引用

页码：216 / 225

页数：10

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