Chemoenzymatic studies: From cycloheptatriene to the core of zaragozic acids

被引：24

作者：

Xu, YP ^{[1
]}

Johnson, CR ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48202

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(97)00086-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(1R,4S,6S)-4-Acetoxy-6-triisopropylsilyloxy-2-cyclohepten-1-ol, prepared from cycloheptatriene utilizing an asymmetrization of the precursor diol with Candida antarctica lipase B/isopropenyl acetate, was converted to (1S,3R,4S,5S,6R,7R)-4,6,7-triacetoxy-5-benzyloxymethyl-4- acetoxyethyl-2,8-dioxabicyclo[3.2.1]octane representing the core of zaragozic acid by a strategy involving Rubottom oxidations and ozonolysis. (C) 1997, Elsevier Science Ltd.

引用

页码：1117 / 1120

页数：4

共 18 条

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