Sirt1: a metabolic master switch that modulates lifespan

被引：98

作者：

Leibiger, IB ^{[1
]}

Berggren, PO ^{[1
]}

机构：

[1] Karolinska Inst, Rolf Luft Res Ctr Diabet & Endocrinol, SE-17176 Stockholm, Sweden

来源：

NATURE MEDICINE | 2006年 / 12卷 / 01期

关键词：

D O I：

10.1038/nm0106-34

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirt1, an enzyme that removes acetyl groups from specific nuclear proteins, has been linked to the regulation of aging. It is now clear that Sirt1 also controls hepatic glucose metabolism by serving as a sensor of the metabolic status in hepatocytes.

引用

页码：34 / 36

页数：4

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