Visualizing and quantifying adhesive signals

被引：27

作者：

Sabouri-Ghomi, Mohsen ^{[2
]}

Wu, Yi ^{[1
]}

Hahn, Klaus ^{[1
]}

Danuser, Gaudenz ^{[2
]}

机构：

[1] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2008.05.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.

引用

页码：541 / 550

页数：10

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