Cancer Epigenetics: From Mechanism to Therapy

被引：2381

作者：

Dawson, Mark A. ^{[1
,2
,3
,4
]}

Kouzarides, Tony ^{[1
,2
]}

机构：

[1] Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QN, England

[3] Univ Cambridge, Cambridge Inst Med Res, Dept Haematol, Cambridge CB2 0XY, England

[4] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 0XY, England

来源：

CELL | 2012年 / 150卷 / 01期

关键词：

HISTONE DEACETYLASE INHIBITORS; IDENTIFIES FREQUENT MUTATION; METHYLTRANSFERASE GENE EZH2; CHROMATIN REMODELING GENES; ACUTE MYELOID-LEUKEMIA; SOMATIC MUTATIONS; DNA METHYLATION; INACTIVATING MUTATIONS; MOLECULAR-MECHANISMS; GENOME;

D O I：

10.1016/j.cell.2012.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epigenetic regulation of DNA-templated processes has been intensely studied over the last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting regulate many biological processes that are fundamental to the genesis of cancer. Here, we present the basic principles behind these epigenetic pathways and highlight the evidence suggesting that their misregulation can culminate in cancer. This information, along with the promising clinical and preclinical results seen with epigenetic drugs against chromatin regulators, signifies that it is time to embrace the central role of epigenetics in cancer.

引用

页码：12 / 27

页数：16

共 116 条

[11] Acetylation inactivates the transcriptional repressor BCL6 [J].

Bereshchenko, OR ;

Gu, W ;

Dalla-Favera, R .

NATURE GENETICS, 2002, 32 (04) :606-613

[12] An operational definition of epigenetics [J].

Berger, Shelley L. ;

Kouzarides, Tony ;

Shiekhattar, Ramin ;

Shilatifard, Ali .

GENES & DEVELOPMENT, 2009, 23 (07) :781-783

[13] Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains [J].

Berman, Benjamin P. ;

Weisenberger, Daniel J. ;

Aman, Joseph F. ;

Hinoue, Toshinori ;

Ramjan, Zachary ;

Liu, Yaping ;

Noushmehr, Houtan ;

Lange, Christopher P. E. ;

van Dijk, Cornelis M. ;

Tollenaar, Rob A. E. M. ;

Van den Berg, David ;

Laird, Peter W. .

NATURE GENETICS, 2012, 44 (01) :40-U62

[14] A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].

Bernstein, BE ;

Mikkelsen, TS ;

Xie, XH ;

Kamal, M ;

Huebert, DJ ;

Cuff, J ;

Fry, B ;

Meissner, A ;

Wernig, M ;

Plath, K ;

Jaenisch, R ;

Wagschal, A ;

Feil, R ;

Schreiber, SL ;

Lander, ES .

CELL, 2006, 125 (02) :315-326

[15] Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation [J].

Bungard, David ;

Fuerth, Benjamin J. ;

Zeng, Ping-Yao ;

Faubert, Brandon ;

Maas, Nancy L. ;

Viollet, Benoit ;

Carling, David ;

Thompson, Craig B. ;

Jones, Russell G. ;

Berger, Shelley L. .

SCIENCE, 2010, 329 (5996) :1201-1205

[16]

Caparros, 2007, EPIGENETICS

[17] Initial genome sequencing and analysis of multiple myeloma [J].

Chapman, Michael A. ;

Lawrence, Michael S. ;

Keats, Jonathan J. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Schinzel, Anna C. ;

Harview, Christina L. ;

Brunet, Jean-Philippe ;

Ahmann, Gregory J. ;

Adli, Mazhar ;

Anderson, Kenneth C. ;

Ardlie, Kristin G. ;

Auclair, Daniel ;

Baker, Angela ;

Bergsagel, P. Leif ;

Bernstein, Bradley E. ;

Drier, Yotam ;

Fonseca, Rafael ;

Gabriel, Stacey B. ;

Hofmeister, Craig C. ;

Jagannath, Sundar ;

Jakubowiak, Andrzej J. ;

Krishnan, Amrita ;

Levy, Joan ;

Liefeld, Ted ;

Lonial, Sagar ;

Mahan, Scott ;

Mfuko, Bunmi ;

Monti, Stefano ;

Perkins, Louise M. ;

Onofrio, Robb ;

Pugh, Trevor J. ;

Rajkumar, S. Vincent ;

Ramos, Alex H. ;

Siegel, David S. ;

Sivachenko, Andrey ;

Stewart, A. Keith ;

Trudel, Suzanne ;

Vij, Ravi ;

Voet, Douglas ;

Winckler, Wendy ;

Zimmerman, Todd ;

Carpten, John ;

Trent, Jeff ;

Hahn, William C. ;

Garraway, Levi A. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Golub, Todd R. .

NATURE, 2011, 471 (7339) :467-472

[18] Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions [J].

Choudhary, Chunaram ;

Kumar, Chanchal ;

Gnad, Florian ;

Nielsen, Michael L. ;

Rehman, Michael ;

Walther, Tobias C. ;

Olsen, Jesper V. ;

Mann, Matthias .

SCIENCE, 2009, 325 (5942) :834-840

[19] Progress in the Discovery of Small-Molecule Inhibitors of Bromodomain-Histone Interactions [J].

Chung, Chun-Wa ;

Witherington, Jason .

JOURNAL OF BIOMOLECULAR SCREENING, 2011, 16 (10) :1170-1185

[20] TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation [J].

Cimmino, Luisa ;

Abdel-Wahab, Omar ;

Levine, Ross L. ;

Aifantis, Iannis .

CELL STEM CELL, 2011, 9 (03) :193-204

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