piRNAs and siRNAs collaborate in Caenorhabditis elegans genome defense

被引：7

作者：

Billi, Allison C. ^{[1
,2
]}

Freeberg, Mallory A. ^{[1
,3
]}

Kim, John K. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Human Genet, Life Sci Inst, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

来源：

GENOME BIOLOGY | 2012年 / 13卷 / 07期

基金：

美国国家科学基金会;

关键词：

piRNA; siRNA; Piwi; C; elegans; germline; genome surveillance; epigenetics; gene silencing; transposable elements; EPIGENETIC MEMORY; GERMLINE; PIWI;

D O I：

10.1186/gb-2012-13-7-164

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Caenorhabditis elegans piRNAs promote genome surveillance by triggering siRNA-mediated silencing of nonself DNA in competition with licensing programs that support endogenous gene expression.

引用

页数：3

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