Enzymatic resolution of secondary alcohols coupled with ruthenium-catalyzed racemization without hydrogen mediator

被引：89

作者：

Koh, JH

Jung, HM

Kim, MJ

Park, J

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

[2] Pohang Univ Sci & Technol, Ctr Biofunct Mol, Pohang 790784, South Korea

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(99)01237-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(eta(5)-Indenyl)RuCl(PPh3)(2) was found to catalyze the racemization of secondary alcohols in the presence of triethylamine and oxygen. Unlike previously reported metal-catalyzed racemizations, ketones were not required as hydrogen mediators in our process. The Ru-catalyzed racemization was coupled with enzymatic acetylation for the dynamic kinetic resolution of secondary alcohols to give chiral acetates in good yields (60-98%) with high enantioselectivities (82-99% ee). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6281 / 6284

页数：4

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