Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation

被引：26

作者：

Saphire, ACS ^{[1
]}

Bobardt, MD ^{[1
]}

Gallay, PA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 09期

关键词：

D O I：

10.1128/JVI.76.9.4671-4677.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cyclophilin A (CypA) is necessary for effective human immunodeficiency virus type 1 (HIV-1) replication. However, the functions of CypA and the precise steps at which CypA acts in the HIV-1 life cycle remain to be determined. By using a methodology that bypasses the need for attachment factors-spinoculation-we present evidence that CypA participates in both entry and postentry events.

引用

页码：4671 / 4677

页数：7

共 29 条

[1] MODE OF ACTION OF SDZ NIM-811, A NONIMMUNOSUPPRESSIVE CYCLOSPORINE-A ANALOG WITH ACTIVITY AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) TYPE-1 - INTERFERENCE WITH HIV PROTEIN-CYCLOPHILIN-A INTERACTIONS [J].

BILLICH, A ;

HAMMERSCHMID, F ;

PEICHL, P ;

WENGER, R ;

ZENKE, G ;

QUESNIAUX, V ;

ROSENWIRTH, B .

JOURNAL OF VIROLOGY, 1995, 69 (04) :2451-2461

[2] Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells [J].

Braaten, D ;

Luban, J .

EMBO JOURNAL, 2001, 20 (06) :1300-1309

[3] Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription [J].

Braaten, D ;

Franke, EK ;

Luban, J .

JOURNAL OF VIROLOGY, 1996, 70 (06) :3551-3560

[4] The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein [J].

Braaten, D ;

Ansari, H ;

Luban, J .

JOURNAL OF VIROLOGY, 1997, 71 (03) :2107-2113

[5] Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization [J].

Colgan, J ;

Yuan, HEH ;

Franke, EK ;

Luban, J .

JOURNAL OF VIROLOGY, 1996, 70 (07) :4299-4310

[6] Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions [J].

Dorfman, T ;

Weimann, A ;

Borsetti, A ;

Walsh, CT ;

Gottlinger, HG .

JOURNAL OF VIROLOGY, 1997, 71 (09) :7110-7113

[7] Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction [J].

Franke, EK ;

Luban, J .

VIROLOGY, 1996, 222 (01) :279-282

[8] SPECIFIC INCORPORATION OF CYCLOPHILIN-A INTO HIV-1 VIRIONS [J].

FRANKE, EK ;

YUAN, HEH ;

LUBAN, J .

NATURE, 1994, 372 (6504) :359-362

[9] New methods for analyzing compounds on polymeric supports [J].

Gallop, MA ;

Fitch, WL .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1997, 1 (01) :94-100

[10] Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid [J].

Gamble, TR ;

Vajdos, FF ;

Yoo, SH ;

Worthylake, DK ;

Houseweart, M ;

Sundquist, WI ;

Hill, CP .

CELL, 1996, 87 (07) :1285-1294

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