DAS181 treatment of hematopoietic stem cell transplant patients with parainfluenza virus lung disease requiring mechanical ventilation

被引：31

作者：

Chalkias, S. ^{[1
,2
]}

Mackenzie, M. R. ^{[2
]}

Gay, C. ^{[3
]}

Dooley, C. ^{[4
]}

Marty, F. M. ^{[3
]}

Moss, R. B. ^{[5
]}

Li, T. ^{[5
]}

Routh, R. L. ^{[5
]}

Walsh, S. R. ^{[2
,3
]}

Tan, C. S. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Infect Dis, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Dept Med, Boston, MA 02215 USA

[3] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[4] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pharm, Boston, MA 02215 USA

[5] Ansun BioPharma, San Diego, CA USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2014年 / 16卷 / 01期

关键词：

parainfluenza; DAS181; HSCT; mechanical ventilation; INFECTIONS; THERAPY; RISK;

D O I：

10.1111/tid.12177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Parainfluenza infection is a cause of significant morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) patients. DAS181 is a novel antiviral agent with activity against influenza and parainfluenza. We report the first 2 cases, to our knowledge, of successful DAS181 use in ventilated HSCT patients with severe parainfluenza lung disease.

引用

页码：141 / 144

页数：4

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