p38 MAP kinase: a convergence point in cancer therapy

被引：274

作者：

Olson, JM ^{[1
]}

Hallahan, AR

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[2] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 03期

关键词：

D O I：

10.1016/j.molmed.2004.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies show that activation of p38 mitogen-activated protein kinase (MAPK) results in cancer cell apoptosis initiated by retinoids, cisplatin and other chemotherapeutic agents. The observation that divergent therapies act through a common signal transduction pathway raises the possibility of developing new anti-cancer agents that lack the side-effects caused by events upstream of p38 MAPK. Here, we review p38-MAPK-mediated tumor cell apoptosis and implications for cancer therapeutics.

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收藏

页码：125 / 129

页数：5

相关论文

共 46 条

[1] ERK-8, a new member of the mitogen-activated protein kinase family [J].

Abe, MK ;

Saelzler, MP ;

Espinosa, R ;

Kahle, KT ;

Hershenson, MB ;

Le Beau, MM ;

Rosner, MR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (19) :16733-16743

[2]

Abe MK, 1999, MOL CELL BIOL, V19, P1301

[3] Okadaic acid and anisomycin are protective and stimulate the SAP/JNK pathway [J].

Barancik, M ;

Htun, P ;

Schaper, W .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1999, 34 (02) :182-190

[4] Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation [J].

Bulavin, DV ;

Saito, S ;

Hollander, MC ;

Sakaguchi, K ;

Anderson, CW ;

Appella, E ;

Fornace, AJ .

EMBO JOURNAL, 1999, 18 (23) :6845-6854

[5] Mammalian MAP kinase signalling cascades [J].

Chang, LF ;

Karin, M .

NATURE, 2001, 410 (6824) :37-40

[6]

Deacon K, 2003, MOL BIOL CELL, V14, P2071, DOI 10.1091/mbc.e02-10-0653

[7] p38 mitogen-activated protein kinases on the body surface -: A function for p38δ [J].

Eckert, RL ;

Efimova, T ;

Balasubramanian, S ;

Crish, JF ;

Bone, F ;

Dashti, S .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (05) :823-828

[8] Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6 [J].

Enslen, H ;

Raingeaud, J ;

Davis, RJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (03) :1741-1748

[9] AN OSMOSENSING SIGNAL-TRANSDUCTION PATHWAY IN MAMMALIAN-CELLS [J].

GALCHEVAGARGOVA, Z ;

DERIJARD, B ;

WU, IH ;

DAVIS, RJ .

SCIENCE, 1994, 265 (5173) :806-808

[10] Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor γ2 [J].

Gianni, M ;

Kopf, E ;

Bastien, J ;

Oulad-Abdelghani, M ;

Garattini, E ;

Chambon, P ;

Rochette-Egly, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) :24859-24862

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