Prognostic value of telomere length in acute coronary syndrome

被引：8

作者：

Perez-Rivera, Jose-Angel ^{[1
]}

Pabon-Osuna, Pedro ^{[1
]}

Cieza-Borrella, Clara ^{[2
,3
]}

Martin-Herrero, Francisco ^{[1
]}

Gonzalez-Porras, Jose-Ramon ^{[4
]}

Gonzalez-Sarmiento, Rogelio ^{[2
,3
]}

机构：

[1] IBSAL Univ Hosp Salamanca, Dept Cardiol, Salamanca 37007, Spain

[2] Univ Salamanca, CSIC, Dept Med, IBSAL,IBMCC, E-37008 Salamanca, Spain

[3] Univ Salamanca, CSIC, Dept Med, Mol Med Unit, E-37008 Salamanca, Spain

[4] IBSAL Univ Hosp Salamanca, Dept Hematol, Salamanca 37007, Spain

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2012年 / 133卷 / 11-12期

关键词：

Telomere length; Telomerase polymorphisms; Acute coronary syndrome; Cellular ageing; Cardiovascular prognosis; QUANTITATIVE PCR; HEART-DISEASE; ASSOCIATION;

D O I：

10.1016/j.mad.2012.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Telomere and telomerase are involved in cellular and organismal ageing and have been related to human diseases. Coronary artery disease is one of the most common age-related health problems in developed countries. Nevertheless, the specific role of cellular ageing in this process is still unclear. In this study, we analyze the possible prognostic value of telomere length and telomerase polymorphisms in a population of 150 middle aged males (mean age 62 +/- 7) admitted for acute coronary syndrome who were followed up for more than 600 days. Peripheral blood samples were obtained and relative and comparative qPCR was used to measure telomere length and real time PCR to study the polymorphisms. Two prognostic combined events were defined. Long telomere length was revealed as an independent predictor (protector) of combined event presentation during long term follow up in our patients. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：695 / 697

页数：3

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