Sirtuin Catalysis and Regulation

被引:192
作者
Feldman, Jessica L.
Dittenhafer-Reed, Kristin E.
Denu, John M. [1 ]
机构
[1] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53715 USA
关键词
FATTY-ACID OXIDATION; SMALL-MOLECULE ACTIVATORS; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SUBSTRATE-SPECIFICITY; LYSINE PROPIONYLATION; CALORIE RESTRICTION; CELL-SURVIVAL; SIR2; PROTEIN; DEACETYLASE; MECHANISM;
D O I
10.1074/jbc.R112.378877
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sirtuins are a family of NAD(+)-dependent protein deacetylases/deacylases that dynamically regulate transcription, metabolism, and cellular stress response. Their general positive link with improved health span in mammals, potential regulation of pathways mediated by caloric restriction, and growing links to human disease have spurred interest in therapeutics that target their functions. Here, we review the current understanding of the chemistry of catalysis, biological targets, and endogenous regulation of sirtuin activity. We discuss recent efforts to generate small-molecule regulators of sirtuin activity.
引用
收藏
页码:42419 / 42427
页数:9
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