A systems biology analysis of autophagy in cancer therapy

被引：40

作者：

Shi, Zheng ^{[1
,2
,3
]}

Li, Chun-yang ^{[1
,2
]}

Zhao, Si ^{[1
,2
]}

Yu, Yang ^{[1
,2
]}

An, Na ^{[1
,2
]}

Liu, Yong-xi ^{[1
,2
]}

Wu, Chuan-fang ^{[1
,2
]}

Yue, Bi-song ^{[1
,2
]}

Bao, Jin-ku ^{[1
,2
]}

机构：

[1] Sichuan Univ, Sch Life Sci, Minist Educ, Chengdu 610064, Peoples R China

[2] Sichuan Univ, Key Lab Bioresources, Minist Educ, Chengdu 610064, Peoples R China

[3] Guizhou Normal Univ, Sch Life Sci, Guiyang 550001, Peoples R China

来源：

CANCER LETTERS | 2013年 / 337卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Autophagy; Cancer; Systems biology; Therapy; Drug discovery; TUMOR-SUPPRESSOR GENE; MALIGNANT GLIOMA-CELLS; SIGNALING PATHWAYS; PROTEIN-KINASE; TUBEROUS SCLEROSIS; REGULATES AUTOPHAGY; BH3-ONLY PROTEINS; DRUG-COMBINATIONS; CARCINOMA-CELLS; DAP-KINASE;

D O I：

10.1016/j.canlet.2013.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Autophagy, which degrades redundant or damaged cellular constituents, is intricately relevant to a variety of human diseases, most notably cancer. Autophagy exerts distinct effects on cancer initiation and progression, due to the intrinsic overlapping of autophagic and cancer signalling pathways. However, due to the complexity of cancer as a systemic disease, the fate of cancer cells is not decided by any one signalling pathway. Numerous autophagic inter-connectivity and cross-talk pathways need to be further clarified at a systems level. In this review, we propose a systems biology perspective for the comprehensive analysis of the autophagy-cancer network, focusing on systems biology analysis in autophagy and cancer therapy. Together, these analyses may not only improve our understanding on autophagy-cancer relationships, but also facilitate cancer drug discovery. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：149 / 160

页数：12

共 151 条

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Tissue transglutaminase inhibits autophagy in pancreatic cancer cells [J].