Synthetic library techniques: Subjective (biased and generic) thoughts and views

被引：21

作者：

Krchnak, V ^{[1
]}

Lebl, M ^{[1
]}

机构：

[1] SELECTIDE CORP,TUCSON,AZ 85737

来源：

MOLECULAR DIVERSITY | 1996年 / 1卷 / 03期

关键词：

synthetic libraries; peptide libraries; one-bead-one-compound libraries; deconvolution; diversity; screening approaches;

D O I：

10.1007/BF01544958

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various aspects of synthetic diversity generation and screening are discussed. Controversial issues are raised and different points of view are presented. We hope the article will stimulate thinking about the utilization of library techniques and start a discussion about questions concerning their application.

引用

页码：193 / 216

页数：24

共 147 条

[31] ELLMAN JA, 1996, CHEM REV, V96, P555
[32] FASSINA G, 1994, PROTEIN PEPTIDE LETT, V1, P15
[33] FEURER M, 1978, PEPTIDES, P448
[34] HIGH-RESOLUTION H-1-NMR IN SOLID-PHASE ORGANIC-SYNTHESIS
FITCH, WL
DETRE, G
HOLMES, CP
SHOOLERY, JN
KEIFER, PA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (26) : 7955 - 7956
[35] LIGHT-DIRECTED, SPATIALLY ADDRESSABLE PARALLEL CHEMICAL SYNTHESIS
FODOR, SPA
READ, JL
PIRRUNG, MC
STRYER, L
LU, AT
SOLAS, D
[J]. SCIENCE, 1991, 251 (4995) : 767 - 773
[36] SPOT-SYNTHESIS - AN EASY TECHNIQUE FOR THE POSITIONALLY ADDRESSABLE, PARALLEL CHEMICAL SYNTHESIS ON A MEMBRANE SUPPORT
FRANK, R
[J]. TETRAHEDRON, 1992, 48 (42) : 9217 - 9232
[37] SIMULTANEOUS MULTIPLE PEPTIDE-SYNTHESIS UNDER CONTINUOUS-FLOW CONDITIONS ON CELLULOSE PAPER DISKS AS SEGMENTAL SOLID SUPPORTS
FRANK, R
DORING, R
[J]. TETRAHEDRON, 1988, 44 (19) : 6031 - 6040
[38] STRATEGIES AND TECHNIQUES IN SIMULTANEOUS SOLID-PHASE SYNTHESIS BASED ON THE SEGMENTATION OF MEMBRANE TYPE SUPPORTS
FRANK, R
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (03) : 425 - 430
[39] FRANK R, 1994, INNOVATION PERSPECTI, P509
[40] SYNTHESIS AND APPLICATIONS OF ORGANIC POLYMERS AS SUPPORTS AND PROTECTING GROUPS
FRECHET, JMJ
[J]. TETRAHEDRON, 1981, 37 (04) : 663 - 683

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