Protein structure modeling for structural genomics

被引:155
作者
Sánchez, R [1 ]
Pieper, U [1 ]
Melo, F [1 ]
Eswar, N [1 ]
Martí-Renom, MA [1 ]
Madhusudhan, MS [1 ]
Mirkovic, N [1 ]
Sali, A [1 ]
机构
[1] Rockefeller Univ, Pels Family Ctr Biochem & Struct Biol, Labs Mol Biophys, New York, NY 10021 USA
关键词
D O I
10.1038/80776
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The shapes of most protein sequences will be modeled based on their similarity to experimentally determined protein structures. The current role, limitations, challenges and prospects for protein structure modeling (using information about genes and genomes) are discussed in the context of structural genomics.
引用
收藏
页码:986 / 990
页数:5
相关论文
共 35 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]   Automated genome sequence analysis and annotation [J].
Andrade, MA ;
Brown, NP ;
Leroy, C ;
Hoersch, S ;
de Daruvar, A ;
Reich, C ;
Franchini, A ;
Tamames, J ;
Valencia, A ;
Ouzounis, C ;
Sander, C .
BIOINFORMATICS, 1999, 15 (05) :391-412
[3]   A surprising simplicity to protein folding [J].
Baker, D .
NATURE, 2000, 405 (6782) :39-42
[4]   GenBank [J].
Benson, DA ;
Karsch-Mizrachi, I ;
Lipman, DJ ;
Ostell, J ;
Rapp, BA ;
Wheeler, DL .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :15-18
[5]   The Protein Data Bank [J].
Berman, HM ;
Westbrook, J ;
Feng, Z ;
Gilliland, G ;
Bhat, TN ;
Weissig, H ;
Shindyalov, IN ;
Bourne, PE .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242
[6]   KNOWLEDGE-BASED PREDICTION OF PROTEIN STRUCTURES AND THE DESIGN OF NOVEL MOLECULES [J].
BLUNDELL, TL ;
SIBANDA, BL ;
STERNBERG, MJE ;
THORNTON, JM .
NATURE, 1987, 326 (6111) :347-352
[7]   The PRESAGE database for structural genomics [J].
Brenner, SE ;
Barken, D ;
Levitt, M .
NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :251-253
[8]  
Brenner SE, 2000, PROTEIN SCI, V9, P197
[9]  
Brooks C. L., 1988, PROTEINS THEORETICAL
[10]   Structural genomics: beyond the Human Genome Project [J].
Burley, SK ;
Almo, SC ;
Bonanno, JB ;
Capel, M ;
Chance, MR ;
Gaasterland, T ;
Lin, DW ;
Sali, A ;
Studier, FW ;
Swaminathan, S .
NATURE GENETICS, 1999, 23 (02) :151-157