Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes

被引：105

作者：

Bai, Peter ^{[1
]}

Virag, Laszlo

机构：

[1] Univ Debrecen, Dept Med Chem, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

来源：

FEBS LETTERS | 2012年 / 586卷 / 21期

关键词：

Inflammation; Allergy; Oxidative stress; Nitrosative stress; Chemokine; Adhesion molecule; Gene expression; ADP-RIBOSE POLYMERASE; E-DEFICIENT MICE; DIABETIC ENDOTHELIAL DYSFUNCTION; INDUCED CONTACT HYPERSENSITIVITY; KAPPA-B ACTIVATION; NITRIC-OXIDE; DNA-DAMAGE; PHARMACOLOGICAL INHIBITION; CELL-DEATH; OXIDATIVE STRESS;

D O I：

10.1016/j.febslet.2012.09.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3771 / 3777

页数：7

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