V(D)J recombination: on the cutting edge

被引：48

作者：

Oettinger, MA ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(99)80044-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vertebrate immune system has evolved an elegant mechanism for generating an enormous diversity in antigen receptor binding specificity from a limited amount of genetic information. Recent advances are rapidly increasing our understanding of this unusual site-specific DNA rearrangement that assembles the antigen receptor genes during lymphoid development.

引用

页码：325 / 329

页数：5

共 40 条

[1] Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system [J].

Agrawal, A ;

Eastman, QM ;

Schatz, DG .

NATURE, 1998, 394 (6695) :744-751

[2] RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination [J].

Agrawal, A ;

Schatz, DG .

CELL, 1997, 89 (01) :43-53

[3] Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences [J].

Akamatsu, Y ;

Oettinger, MA .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (08) :4670-4678

[4] IDENTIFICATION OF RESIDUES IN THE MU-TRANSPOSASE ESSENTIAL FOR CATALYSIS [J].

BAKER, TA ;

LUO, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6654-6658

[5] Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster [J].

Bellon, SF ;

Rodgers, KK ;

Schatz, DG ;

Coleman, JE ;

Steitz, TA .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (07) :586-591

[6] Hairpin coding end opening is mediated by RAG1 and RAG2 proteins [J].

Besmer, E ;

Mansilla-Soto, J ;

Cassard, S ;

Sawchuk, DJ ;

Brown, G ;

Sadofsky, M ;

Lewis, SM ;

Nussenzweig, MC ;

Cortes, P .

MOLECULAR CELL, 1998, 2 (06) :817-828

[7] Mechanism of V(D)J recombination [J].

Bogue, M ;

Roth, DB .

CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (02) :175-180

[8] REVERSAL OF INTEGRATION AND DNA SPLICING MEDIATED BY INTEGRASE OF HUMAN-IMMUNODEFICIENCY-VIRUS [J].

CHOW, SA ;

VINCENT, KA ;

ELLISON, V ;

BROWN, PO .

SCIENCE, 1992, 255 (5045) :723-726

[9] UNITY IN TRANSPOSITION REACTIONS [J].

CRAIG, NL .

SCIENCE, 1995, 270 (5234) :253-254

[10] DNA-end-joining: from yeast to man [J].

Critchlow, SE ;

Jackson, SP .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (10) :394-398

← 1 2 3 4 →