Preference and acceptability of oral versus vaginal administration of misoprostol in medical abortion with mifepristone

Objectives: To compare the experience of pain, need of analgesic interventions, preference and acceptability in medical abortion up to 49 days of amenorrhea with mifepristone and orally versus vaginally administered misoprostol. Study Design: Ninety-seven women were randomised to oral misoprostol, n = 48, or vaginal misoprostol, n = 49. On day 1 of the study, both the groups received 600 mg of mifepristone. On day 3 of the study, one group received 0.4 mg of misoprostol orally and the other group received 0.8 mg of misoprostol vaginally. Results: Even though oral administration of misoprostol seemed to be associated with a higher rate of gastrointestinal side effects, women in both the groups showed a clear preference towards the oral route of administration. The willingness to administer the misoprostol at home was also higher among the women in the oral group, which may in part depend on a more positive/less negative experience of the abortion. Conclusion: A majority of women prefer oral administration of misoprostol in early medical abortion. (C) 2005 Elsevier Ireland Ltd. All rights reserved.