Efficient synthesis of 2-deoxy-L-erythro-pentose (2-deoxy-L-ribose) from L-arabinose

被引：23

作者：

Chong, YH ^{[1
]}

Chu, CK ^{[1
]}

机构：

[1] Univ Georgia, Coll Pharm, Ctr Drug Discovery, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA

来源：

CARBOHYDRATE RESEARCH | 2002年 / 337卷 / 05期

关键词：

2-deoxy-L-erythro-pentose; 2-deoxy-L-ribose; L-nucleosides; L-arabinose; free-radical deoxygenation;

D O I：

10.1016/S0008-6215(01)00329-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient and practical route for the large-scale synthesis of 2-deoxy-L-erythro-pentose (2-deoxy-L-ribose) starting from L-arabinose was developed using Barton-type free-radical deoxygenation reaction as a key step. The radical precursor. a phenoxythiocarbonyl ester, was prepared in situ. and the most efficient deoxygenation was achieved by slow addition of tributyltin hydride to the reaction mixture. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：397 / 402

页数：6

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