A convenient synthesis of chiral 1,2,4-oxadiazoles from N-protected (α-aminoacyl)benzotriazoles

被引：61

作者：

Katritzky, AR ^{[1
]}

Shestopalov, AA ^{[1
]}

Suzuki, K ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

ARKIVOC | 2005年

关键词：

chiral 1,2,4-oxadiazole; N-aminoacylbenzotriazole; N-acylbenzotriazole; benzotriazole methodology;

D O I：

10.3998/ark.5550190.0006.705

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2,4-Oxadiazoles (4a-k, 6a-c, 7a-d, and 11a-f) derived from chiral alpha-amino acids were synthesized in 70-94% yields via a fast and easy procedure under mild conditions. They were shown to be at least 97% enantiomerically pure by HPLC and NMR.

引用

页码：36 / 55

页数：20

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