Structure-activity relationships of a novel class of Src SH2 inhibitors

被引：52

作者：

Buchanan, JL ^{[1
]}

Vu, CB ^{[1
]}

Merry, TJ ^{[1
]}

Corpuz, EG ^{[1
]}

Pradeepan, SG ^{[1
]}

Mani, UN ^{[1
]}

Yang, M ^{[1
]}

Plake, HR ^{[1
]}

Varkhedkar, VM ^{[1
]}

Lynch, BA ^{[1
]}

MacNeil, IA ^{[1
]}

Loiacono, KA ^{[1
]}

Tiong, CL ^{[1
]}

Holt, DA ^{[1
]}

机构：

[1] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(99)00389-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4- and 2,5-substituted thiazoles and 1,2,4-oxadiazoles as scaffolds resulted in inhibitors that bound as well as the standard tetrapeptide Ac-pYEEI-NH2. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2359 / 2364

页数：6

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