Structure-based design and synthesis of a novel class of Src SH2 inhibitors

被引：39

作者：

Buchanan, JL ^{[1
]}

Bohacek, RS ^{[1
]}

Luke, GP ^{[1
]}

Hatada, M ^{[1
]}

Lu, XD ^{[1
]}

Dalgarno, DC ^{[1
]}

Narula, SS ^{[1
]}

Yuan, R ^{[1
]}

Holt, DA ^{[1
]}

机构：

[1] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(99)00388-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2353 / 2358

页数：6

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