Adenosine receptor ligands with oxygenated N6-substituents

被引：10

作者：

Hutchinson, SA

Baker, SP

Scammells, PJ ^{[1
]}

机构：

[1] Deakin Univ, Sch Biol & Chem Sci, Geelong, Vic 3217, Australia

[2] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(99)00109-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of novel adenosine analogs bearing oxygenated substituents in the N-6-position have been prepared and evaluated as A(1) adenosine agonists. Improved conditions far the synthesis of N-6-substituted adenosines and a new one pot procedure for the synthesis of 2-amino-7-oxabicyclo[2.2.1]hept-5-ene are also reported. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：933 / 936

页数：4

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